Plant Comparison

Aloe Vera vs Chaga

A side-by-side comparison of two medicinal plants — every documented constituent, action, use, safety note and cited source, assembled automatically from the Omnia Sana database.

First plant
Second plant
Show:
Plant AAloe VeraAloe veraAsphodelaceaeFull monograph →
Plant BChagaInonotus obliquusHymenochaetaceaeFull monograph →

At a glance

Aloe Vera and Chaga: they share 6 indicated uses (arthritis / joint pain, cancer (anticancer research), infection (general), …); 3 pharmacological actions in common.

Aloe VeraChaga
Constituents33
Pharmacological actions610
Indicated uses1111
Safety notes22
Cited sources3241
Indicated uses
Only Aloe Vera
Back painBruisingEczemaHeadachePain (general)
Shared (6)
Arthritis / joint painCancer (anticancer research)Infection (general)Inflammation (general)Skin irritationWounds
Only Chaga
Cold & fluImmune supportMetabolic supportCognitive functionCardiovascular / heart health
Pharmacological actions
Only Aloe Vera
Analgesic (pain relief)Emollient / skin-soothingVulnerary (wound healing)
Shared (3)
Anti-inflammatoryAnticancer (preclinical)Antimicrobial
Only Chaga
AntioxidantImmunomodulator / immune supportNephroprotective (kidney support)Neuroprotective / cognition supportAntidiabetic (blood-sugar lowering)Hepatoprotective (liver support)Lipid-lowering

Evidence face-off — shared uses

ConditionAloe VeraChagaVerdict
Arthritis / joint pain1/101/10Comparable evidence
Cancer (anticancer research)2/102/10Comparable evidence
Infection (general)1/101/10Comparable evidence
Inflammation (general)1/101/10Comparable evidence
Skin irritation1/101/10Comparable evidence
Wounds1/101/10Comparable evidence

Evidence scores (1–10) are computed from the tier of each cited source. “Comparable” means the two scores are within one point. Follow a score to its detailed sources.

Key Constituents

Polysaccharides (acemannan)[1, 13]

Acemannan and other glucomannans are the principal gel polysaccharides, underlying the emollient and wound-healing effects.

PolysaccharidesMucilage
Anthraquinones (aloin, aloe-emodin)[1]

Found mainly in the leaf latex (not the inner gel); responsible for the traditional laxative effect and requiring caution with prolonged use.

Anthraquinones
Enzymes, vitamins and minerals[1]

Minor bioactive enzymes, vitamins (including C and E) and minerals contribute to the antioxidant and skin-conditioning properties of the gel.

Melanin-rich pigments and betulinic acid derivatives[1]

Chaga's dark colour comes from melanin-like pigments; it also concentrates betulinic-acid-type triterpenes absorbed from its birch host, associated with antioxidant and anticancer research interest.

Polysaccharides (beta-glucans)[4]

Immunomodulatory polysaccharides contributing to the traditional tonic and immune-support use.

Polysaccharides
Phenolic compounds[4]

Antioxidant phenolics contributing to chaga's free-radical-scavenging activity.

Phenolic compounds

Pharmacological Actions

Analgesic (pain relief)[13, 14, 15, 16, 17, 18, 19, 20]
Anti-inflammatory[1, 2, 7, 10, 11, 13, 14, 15, 16, 17, 18, 19, 20]
Anticancer (preclinical)[21, 22, 23, 24, 25, 26]

Aloe vera and its anthraquinone aloe-emodin show dose-dependent antiproliferative and pro-apoptotic activity against multiple cancer types in vitro and in vivo (preclinical).

Antimicrobial[1, 3, 9, 11, 13, 14, 15, 16, 17, 18, 19, 20]
Emollient / skin-soothing[4, 13, 14, 15, 16, 17, 18, 19, 20]
Vulnerary (wound healing)[4, 5, 8, 10, 13, 14, 15, 16, 17, 18, 19, 20]
Anti-inflammatory[4, 5, 9, 13, 15, 19, 27, 30, 38, 39, 40]
Anticancer (preclinical)[15, 17, 21, 22, 26, 28, 31, 38]
Antimicrobial[38, 39, 40]
Antioxidant[8, 10, 12, 29, 35, 38, 39, 40]
Immunomodulator / immune support[2, 4, 7, 14, 16, 19, 26, 32, 37, 38, 39, 40]
Nephroprotective (kidney support)[20]
Neuroprotective / cognition support[24, 35]
Antidiabetic (blood-sugar lowering)[25, 31, 34, 36]
Hepatoprotective (liver support)[28]
Lipid-lowering[33, 36]

Traditional & Indicated Uses

Arthritis / joint pain[13, 14, 15, 16, 17, 18, 19, 20]Traditional · 1/10

inferred from anti-inflammatory action

Evidence: 1
Label: Arthritis / joint pain
Back pain[13, 14, 15, 16, 17, 18, 19, 20]Traditional · 1/10

inferred from analgesic action

Evidence: 1
Label: Back pain
Bruising[13, 14, 15, 16, 17, 18, 19, 20]Traditional · 1/10

inferred from vulnerary action

Evidence: 1
Label: Bruising
Cancer (anticancer research)[21, 22, 23, 24, 25, 26]Traditional · 2/10

Aloe-emodin, an Aloe vera anthraquinone, induces apoptosis and inhibits growth of gastric, oral squamous, hepatocellular, lung (incl. xenograft) and glioblastoma cancer cells, modulating caspases, Bcl-2/Bax, PI3K/Akt and MEK/ERK signalling (preclinical).

Evidence: 2
Label: Cancer (anticancer research)
Eczema[13, 14, 15, 16, 17, 18, 19, 20]Traditional · 1/10

inferred from emollient action

Evidence: 1
Label: Eczema
Headache[13, 14, 15, 16, 17, 18, 19, 20]Traditional · 1/10

inferred from analgesic action

Evidence: 1
Label: Headache
Infection (general)[13, 14, 15, 16, 17, 18, 19, 20]Traditional · 1/10

inferred from antimicrobial action

Evidence: 1
Label: Infection (general)
Inflammation (general)[13, 14, 15, 16, 17, 18, 19, 20]Traditional · 1/10

inferred from anti-inflammatory action

Evidence: 1
Label: Inflammation (general)
Pain (general)[13, 14, 15, 16, 17, 18, 19, 20]Traditional · 1/10
Evidence: 1
Label: Pain (general)
Skin irritation[13, 14, 15, 16, 17, 18, 19, 20]Traditional · 1/10

inferred from anti-inflammatory action

Evidence: 1
Label: Skin irritation
Wounds[13, 14, 15, 16, 17, 18, 19, 20]Traditional · 1/10

inferred from antimicrobial action

Evidence: 1
Label: Wounds
Arthritis / joint pain[38, 39, 40]Traditional · 1/10

inferred from anti-inflammatory action

Evidence: 1
Label: Arthritis / joint pain
Cancer (anticancer research)[15, 21, 38]Traditional · 2/10

inferred from anticancer action

Evidence: 2
Label: Cancer (anticancer research)
Cold & flu[38, 39, 40]Traditional · 1/10

inferred from immunomodulator action

Evidence: 1
Label: Cold & flu
Immune support[14, 38, 39, 40]Traditional · 2/10
Evidence: 2
Label: Immune support
Infection (general)[38, 39, 40]Traditional · 1/10

inferred from antimicrobial action

Evidence: 1
Label: Infection (general)
Inflammation (general)[38, 39, 40]Traditional · 1/10

inferred from anti-inflammatory action

Evidence: 1
Label: Inflammation (general)
Metabolic support[38, 39, 40]Traditional · 1/10
Evidence: 1
Label: Metabolic support
Skin irritation[38, 39, 40]Traditional · 1/10

inferred from anti-inflammatory action

Evidence: 1
Label: Skin irritation
Wounds[38, 39, 40]Traditional · 1/10

inferred from antimicrobial action

Evidence: 1
Label: Wounds
Cognitive function[24, 35]Traditional · 2/10

Chaga-derived 3,4-DHBA protected against Parkinson's-related neurotoxicity (preclinical).

Evidence: 2
Label: Cognitive function
Cardiovascular / heart health[33]Traditional · 2/10

Chaga polysaccharide lowered lipids in vivo and in vitro.

Evidence: 2
Label: Cardiovascular / heart health

Safety, Cautions & Contraindications

Safety note[13, 14, 15, 16, 17, 18, 19, 20]Caution

Topical use of aloe gel is generally safe for most people. Oral use of aloe latex as a laxative is potentially unsafe with prolonged use due to risk of dehydration, electrolyte imbalance, and potential kidney damage. Aloe latex contains anthraquinone glycosides which may cause abdominal cramping and diarrhea. Not recommended during pregnancy or breastfeeding. May interact with diabetes medications, diuretics, and laxatives. Oral aloe gel at typical doses appears safe short-term but long-term safety is unclear. Allergic reactions possible in sensitive individuals.

Safety note[13, 14, 15, 16, 17, 18, 19, 20, 27]Caution

Duke (2002) reports clinical evidence (score 2/3) supporting aloe gel's use in psoriasis, constipation (in adults), and as a vulnerary. Gel preparations have been clinically validated for peptic ulcers (excluding stress-induced), radiation burns, and skin ulcers. Dose: 1 tablespoon gel three times daily or 50–200 mg dried juice equivalent per day as a laxative. An important safety distinction is made: the gel (inner leaf mucilage) is AHPA Class 1 (safe), while the inner leaf juice or dried latex is Class 2b due to anthraquinone content and is contraindicated in intestinal inflammation, colitis, Crohn's disease, appendicitis, and during menstruation (Duke, 2002).

Safety note[38, 39, 40]Caution

Autoimmune conditions: Chaga can stimulate parts of the immune system—people with autoimmune diseases should be cautious.Blood thinners: Chaga contains compounds that may affect clotting—avoid large doses if on anticoagulants.Blood sugar meds: May slightly lower glucose—monitor if taking diabetes medication.Pregnancy & breastfeeding: Limited safety data—best avoided unless guided by a professional.Quality matters: Wild-harvested Chaga can accumulate heavy metals from trees and soil—source from reputable suppliers.

Safety note[38, 39, 40, 41]Info

Duke (2002) does not include a dedicated entry for chaga (Inonotus obliquus) in the Handbook of Medicinal Herbs, Second Edition, as this medicinal fungus was not widely documented in Western herbal literature at that time (Duke, 2002).

External Ids

Gbif: 2777724
Powo: urn:lsid:ipni.org:names:530017-1
Wikidata: Q80079
Gbif: 2521089
Wikidata: Q1956937

Botanical Description

Succulent, rosette-forming perennial with thick, fleshy, lance-shaped leaves edged with soft, pale teeth, each leaf filled with a clear, slippery, mucilaginous gel beneath a tougher green rind. In favourable conditions it produces a tall flowering spike bearing tubular yellow (sometimes orange) flowers.[1]

Height: Leaves 40-80 cm; flower spike to about 1 m
Habit: Succulent, rosette-forming perennial
Leaves: Thick, fleshy, lance-shaped, edged with soft pale teeth, filled with clear mucilaginous gel
Flowers: Tubular yellow (occasionally orange) flowers on a tall, unbranched or sparsely branched spike
Stem: Very short, often inconspicuous, below the leaf rosette
Root: Shallow, fibrous roots
Fruit: Capsule (rarely produced in cultivation)
Flowering Period: Varies with climate; typically under warm, dry conditions

Parasitic wood-decay fungus (not a true plant) that grows almost entirely inside the trunk of living birch trees, visible externally only as a hard, black, cracked, charcoal-like mass (a sclerotium, sometimes called a 'conk') erupting through the bark. Unlike typical mushrooms, chaga has no true cap, gills or stem; its fertile spore-producing surface develops later, hidden beneath the bark after the tree dies.[1]

Height: External mass 10-40 cm
Habit: Parasitic wood-decay fungus, growing mostly inside the host tree
Leaves: Not applicable (fungus)
Flowers: Not applicable (fungus); reproduces by spores
Stem: No true cap-and-stem structure; visible only as a hard black external mass (sclerotium)
Root: Fungal mycelium spreading through the living wood of the host tree
Fruit: Fertile spore-producing layer develops hidden beneath the bark, typically after the host tree dies
Flowering Period: The visible black mass persists and grows for years; not a seasonal fruiting body

Habitat

Believed native to the Arabian Peninsula, and now cultivated and naturalised throughout arid and semi-arid tropical and subtropical regions worldwide as a garden, medicinal and commercial crop.[1]

Grows almost exclusively as a parasite on living birch trees in cold, northern temperate and boreal forests of Europe, Russia, North America and Asia.[1]

Harvesting

Outer, mature leaves are cut close to the base as needed; the clear inner gel (mucilage) is separated from the outer rind and from the bitter yellow latex (aloin-containing exudate) just under the rind, since the gel and the latex have different uses and safety profiles.[1]

Parts: Leaf
Season: Year-round where climate permits, from mature outer leaves

The hard black external mass (conk) is chopped or broken away from the living birch trunk, ideally without killing the tree, then dried and broken into pieces or ground for use; sustainable harvesting (leaving part of the conk to regrow) is recommended given the fungus's slow growth.

Parts: Mycelium, Whole Plant

Traditional Uses

Aloe vera has an ancient reputation, recorded from ancient Egypt onward, as a topical remedy for burns, wounds and skin inflammation (the 'burn plant' / 'first aid plant'), and the bitter leaf latex has been used traditionally as a stimulant laxative. It remains one of the most widely used topical botanicals for skin care and minor wound healing.[1]

Chaga has a long traditional use in Russian, Siberian, Baltic and Scandinavian folk medicine as a tonic remedy for digestive complaints, immune support and general vitality, traditionally taken as a dark, tea-like decoction; this traditional tonic reputation is now studied for its antioxidant, immunomodulatory and anti-inflammatory properties.[1, 4]

Preparations

Fresh gel[1]

Clear inner leaf gel applied fresh, or as a stabilised commercial gel, directly to the skin for burns, minor wounds and skin irritation.

Oral juice/gel[1]

Inner leaf gel (latex-free) taken orally, used traditionally for digestive support.

Decoction[1]

Chunks of the dried black conk simmered gently in water for an extended period, producing a dark, tea-like traditional tonic.

Standardised extract[4]

Extract standardised to polysaccharide or polyphenol content, taken as capsules or powder.

Dosage

Topical gel[12]

The WHO monograph on Aloe Vera Gel specifies fresh gel, or preparations containing 10-70% fresh gel, applied to the affected skin area. Educational reference only, not a prescription.

Not documented

References

REF-2234, REF-2235, REF-2236, REF-2237, REF-2238, REF-2239, REF-2240, REF-2241, REF-2242, REF-2243, REF-2244
REF-0848, REF-0849, REF-0850, REF-2195, REF-2196, REF-2197, REF-2198, REF-2199, REF-2200, REF-2201, REF-2202, REF-2203, REF-2204, REF-2969, REF-2970, REF-2971, REF-2972, REF-2973, REF-2974, REF-2975, REF-2976, REF-2977, REF-2978, REF-2979, REF-2980, REF-2981, REF-2982, REF-2983, REF-2984, REF-2985, REF-2986, REF-2987, REF-2988, REF-2989, REF-2990, REF-2991, REF-2992

Drug Class Interactions

Safety note[28, 29]Caution
Drug Class: antidiabetics
Mechanism: Aloe vera (taken internally) can lower blood sugar - a meta-analysis found improved fasting glucose in prediabetes and improved HbA1c in type 2 diabetes - so combining it with diabetes medicines may increase the risk of hypoglycaemia; monitor blood glucose.
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-03

Not documented

Lookalikes Review

Outcome: has-lookalikes
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-07
Outcome: none-known
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-07

Dangerous Lookalikes

Safety note[30, 31, 32]Irritant
Dangerous Plant: agave-americana
Confused Part: Fleshy leaves harvested for their soothing gel; agave forms a very similar large rosette of thick, pointed succulent leaves.
Confusion Context: Aloe vera is grown and harvested for the clear soothing gel inside its fleshy leaves. Agave (Agave americana and relatives) forms a very similar rosette of thick, pointed succulent leaves and, as Gardening Know How notes, the two are easily confused if you have not grown both. But agave is not soothing: its sap contains calcium oxalate raphides, steroidal saponins and acrid oils, and peer-reviewed dermatology reports document painful irritant contact dermatitis (even purpura) from agave sap. Applying or ingesting agave sap in mistake for aloe gel can burn the skin, mouth and gut. Because both are common houseplants and garden succulents, this is a realistic mix-up.
Distinguishing Features: Inside the leaf (decisive): snap or cut a leaf. Aloe leaves are soft and filled with clear, slippery gel. Agave leaves are tough and fibrous/stringy with no gel - you cannot easily snap them by hand., Leaf tip and edge: agave leaves end in one hard, sharp terminal spine and often have stiff sharp teeth; aloe has softer, more pliable leaves with soft whitish teeth and no rigid terminal spike., Whole plant over time: aloe flowers repeatedly on a branched stalk and lives on; agave typically flowers only once, on a huge tall stalk, then dies.
Key Test: Cut a leaf. Clear, slippery gel inside a soft leaf = aloe (safe gel). A tough, fibrous leaf with no gel, ending in a hard sharp spine = agave - its sap is an irritant that can burn skin, mouth and gut, so do not use it. When in doubt, do not apply or consume it unless you are certain it is aloe.
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-07

Not documented

References & Sources

  1. Sanchez, M., Gonzalez-Burgos, E., Iglesias, I. and Gomez-Serranillos, M.P (2020) 'Pharmacological update properties of Aloe vera and its major active constituents', Molecules, 25(6), pp. 1324. doi:10.3390/molecules25061324 Meta-analysis / review
    https://doi.org/10.3390/molecules25061324
  2. Kaur, S. and Bains, K (2023) 'Aloe barbadensis Miller (Aloe vera)', International Journal for Vitamin and Nutrition Research, 94(3-4), pp. 308-321. doi:10.1024/0300-9831/a000797 Meta-analysis / review
    https://doi.org/10.1024/0300-9831/a000797
  3. Catalano, A., Ceramella, J., Iacopetta, D., Marra, M., Conforti, F., Lupi, F.R., Gabriele, D., Borges, F. and Sinicropi, M.S (2024) 'Aloe vera - an extensive review focused on recent studies', Foods, 13(13), pp. 2155. doi:10.3390/foods13132155 Meta-analysis / review
    https://doi.org/10.3390/foods13132155
  4. Surjushe, A., Vasani, R. and Saple, D.G (2008) 'Aloe vera: a short review', Indian Journal of Dermatology, 53(4), pp. 163-166. doi:10.4103/0019-5154.44785 Meta-analysis / review
    https://doi.org/10.4103/0019-5154.44785
  5. Liang, J., Cui, L., Li, J., Guan, S., Zhang, K. and Li, J (2020) 'Aloe vera: a medicinal plant used in skin wound healing', Tissue Engineering Part B: Reviews, 27(5), pp. 455-474. doi:10.1089/ten.TEB.2020.0236 Meta-analysis / review
    https://doi.org/10.1089/ten.TEB.2020.0236
  6. Guo, X. and Mei, N (2016) 'Aloe vera: a review of toxicity and adverse clinical effects', Journal of Environmental Science and Health Part C, 34(2), pp. 77-96. doi:10.1080/10590501.2016.1166826 Meta-analysis / review
    https://doi.org/10.1080/10590501.2016.1166826
  7. Boyapati, R., Peeta, J., Dhulipalla, R., Kolaparthy, L., Adurty, C. and Cheruvu, R.N.S (2024) 'Comparative evaluation of the efficacy of probiotic, Aloe vera, povidine-iodine, and chlorhexidine mouthwashes in the treatment of gingival inflammation: a randomized controlled trial', Dental and Medical Problems, 61(2), pp. 181-190. doi:10.17219/dmp/156425 Randomized trial
    https://doi.org/10.17219/dmp/156425
  8. Hekmatpou, D., Mehrabi, F., Rahzani, K. and Aminiyan, A (2019) 'The effect of Aloe vera clinical trials on prevention and healing of skin wound: a systematic review', Iranian Journal of Medical Sciences, 44(1), pp. 1-9. Meta-analysis / review
    https://scholar.google.com/scholar?q=The%20effect%20of%20Aloe%20vera%20clinical%20trials%20on%20prevention%20and%20healing%20of%20skin%20wound%3A%20a%20systematic%20review
  9. Gao, Y., Kuok, K.I., Jin, Y. and Wang, R (2018) 'Biomedical applications of Aloe vera', Critical Reviews in Food Science and Nutrition, 59(sup1), pp. S244-S256. doi:10.1080/10408398.2018.1496320 Meta-analysis / review
    https://doi.org/10.1080/10408398.2018.1496320
  10. Feily, A. and Namazi, M.R (2009) 'Aloe vera in dermatology: a brief review', Giornale Italiano di Dermatologia e Venereologia, 144(1), pp. 85-91. Meta-analysis / review
    https://scholar.google.com/scholar?q=Aloe%20vera%20in%20dermatology%3A%20a%20brief%20review
  11. Sierra-Garcia, G.D., Castro-Rios, R., Gonzalez-Horta, A., Lara-Arias, J. and Chavez-Montes, A (2014) 'Acemannan, an extracted polysaccharide from Aloe vera: a literature review', Natural Product Communications, 9(8), pp. 1217-1221. doi:10.1177/1934578x1400900836 Meta-analysis / review
    https://doi.org/10.1177/1934578x1400900836
  12. World Health Organization (1999) 'Aloe Vera Gel'. Available at: https://iris.who.int/items/6418d8af-5200-4e6b-9bf5-004f3aa62a37 Traditional / reference
    https://iris.who.int/items/6418d8af-5200-4e6b-9bf5-004f3aa62a37
  13. Femenia A, Sánchez ES, Simal S, Rosselló C. Compositional features of polysaccharides from Aloe vera (1999) ';39(2):109-117', 39(2). Traditional / reference
    https://scholar.google.com/scholar?q=%3B39%282%29%3A109-117.
  14. Catalano A, Iacopetta D, Ceramella J, et al. Aloe vera - An extensive review focused on recent studies. Foods. 2024;13 (2024) ';13(13):2155', 13(13). Traditional / reference
    https://scholar.google.com/scholar?q=%3B13%2813%29%3A2155.
  15. Hekmatpou D, Mehrabi F, Rahzani K, Aminiyan A. The effect of Aloe vera clinical trials on prevention and healing of skin wound: A systematic review. Iran J Med Sci. 2019;44 (2019) ';44(1):1-9', 44(1). Available at: https://pmc.ncbi.nlm.nih.gov/articles/PMC6330525/ Traditional / reference
    https://pmc.ncbi.nlm.nih.gov/articles/PMC6330525/
  16. National Center for Complementary and Integrative Health. Aloe vera. NIH. 2020. https://www.nccih.nih.gov/health/aloe-vera (2020) 'https://www.nccih.nih.gov/health/aloe-vera'. Available at: https://www.nccih.nih.gov/health/aloe-vera Traditional / reference
    https://www.nccih.nih.gov/health/aloe-vera
  17. Sahu PK, Giri DD, Singh R, et al. Therapeutic and medicinal uses of Aloe vera: A review. Pharmacol Pharm. 2013;4:599-610 (2013) ';4:599-610'. Traditional / reference
    https://scholar.google.com/scholar?q=%3B4%3A599-610.
  18. Sánchez M, González-Burgos E, Iglesias I, Gómez-Serranillos MP. Pharmacological update properties of Aloe vera and its major active constituents. Molecules. 2020;25 (2020) ';25(6):1324', 25(6). Available at: https://pmc.ncbi.nlm.nih.gov/articles/PMC7144722/ Traditional / reference
    https://pmc.ncbi.nlm.nih.gov/articles/PMC7144722/
  19. Surjushe A, Vasani R, Saple DG. Aloe vera: A short review. Indian J Dermatol. 2008;53 (2008) ';53(4):163-166', 53(4). Available at: https://pmc.ncbi.nlm.nih.gov/articles/PMC2763764/ Traditional / reference
    https://pmc.ncbi.nlm.nih.gov/articles/PMC2763764/
  20. Ulbricht C, Armstrong J, Basch E, et al. An evidence-based systematic review of Aloe vera by the Natural Standard Research Collaboration. J Herb Pharmacother. 2008;7 (2008) ';7(3-4):279-323'. Available at: https://www.ncbi.nlm.nih.gov/books/NBK92765/ Traditional / reference
    https://www.ncbi.nlm.nih.gov/books/NBK92765/
  21. Haroon, N. and Amjad, A. and Maaz, M. and Noman, A.M. and Anees, N. and Muhammad, Z. and Shah, M. and Al Abdulmonem, W (2026) 'Phytochemistry, Bioavailability, and Molecular Mechanisms Underlying Multitarget Anticancer Activity of Aloe vera', Nutrients, 18(12), pp. 2034. doi:10.3390/nu18122034 Preclinical
    https://doi.org/10.3390/nu18122034
  22. Chen, S.-H. and Lin, K.-Y. and Chang, C.-C. and Fang, C.-L. and Lin, C.-P (2007) 'Aloe-emodin-induced apoptosis in human gastric carcinoma cells', Food and Chemical Toxicology, 45(11), pp. 2296-2303. doi:10.1016/j.fct.2007.06.005 Preclinical
    https://doi.org/10.1016/j.fct.2007.06.005
  23. Li, Q. and Wen, J. and Yu, K. and Shu, Y. and He, W. and Chu, H. and Zhang, B. and Ge, C (2018) 'Aloe-emodin induces apoptosis in human oral squamous cell carcinoma SCC15 cells', BMC Complementary and Alternative Medicine, 18(1), pp. 296. doi:10.1186/s12906-018-2353-z Preclinical
    https://doi.org/10.1186/s12906-018-2353-z
  24. Arcella, A. and Sanchez, M (2021) 'Natural substances to potentiate canonical glioblastoma chemotherapy', Journal of Chemotherapy, 33(5), pp. 276-287. doi:10.1080/1120009X.2021.1873633 Preclinical
    https://doi.org/10.1080/1120009X.2021.1873633
  25. Zhu, M. and He, Q. and Wang, Y. and Duan, L. and Rong, K. and Wu, Y. and Ding, Y. and Mi, Y. and Ge, X. and Yang, X. and Yu, Y (2023) 'Exploring the mechanism of aloe-emodin in the treatment of liver cancer through network pharmacology and cell experiments', Frontiers in Pharmacology, 14, pp. 1238841. doi:10.3389/fphar.2023.1238841 Preclinical
    https://doi.org/10.3389/fphar.2023.1238841
  26. Kim, H.J. and Choi, J.W. and Ree, J. and Lim, J.S. and Lee, J. and Kim, J.I. and Thapa, S.B. and Sohng, J.K. and Park, Y.I (2022) 'Aloe emodin 3-O-glucoside inhibits cell growth and migration and induces apoptosis of non-small-cell lung cancer cells via suppressing MEK/ERK and Akt signalling pathways', Life Sciences, 300, pp. 120495. doi:10.1016/j.lfs.2022.120495 Preclinical
    https://doi.org/10.1016/j.lfs.2022.120495
  27. Duke, J.A (2002) 'Handbook of Medicinal Herbs, Second Edition'. Traditional / reference
    https://scholar.google.com/scholar?q=Handbook%20of%20Medicinal%20Herbs%2C%20Second%20Edition
  28. Suksomboon, N., Poolsup, N. and Punthanitisarn, S (2016) 'Effect of Aloe vera on glycaemic control in prediabetes and type 2 diabetes: a systematic review and meta-analysis', Journal of Clinical Pharmacy and Therapeutics, 41(2), pp. 180-188. doi:10.1111/jcpt.12382 Meta-analysis / review
    https://doi.org/10.1111/jcpt.12382
  29. Suksomboon, N., Poolsup, N. and Punthanitisarn, S (2016) 'Effect of Aloe vera on glycaemic control in prediabetes and type 2 diabetes: a systematic review and meta-analysis', Journal of Clinical Pharmacy and Therapeutics, 41(2), pp. 180-188. doi:10.1111/jcpt.12382 Meta-analysis / review
    https://doi.org/10.1111/jcpt.12382
  30. Gardening Know How 'Aloe Vs. Agave Plants: What's The Difference Between Aloe And Agave'. Available at: https://www.gardeningknowhow.com/ornamental/cacti-succulents/scgen/how-to-tell-agave-and-aloe-apart.htm Traditional / reference
    https://www.gardeningknowhow.com/ornamental/cacti-succulents/scgen/how-to-tell-agave-and-aloe-apart.htm
  31. Ricks, M.R. and Vogel, P.S. and Elston, D.M. and Hivnor, C (1999) 'Purpuric agave dermatitis', Journal of the American Academy of Dermatology, 40(2 Pt 2), pp. 356-8. doi:10.1016/s0190-9622(99)70485-8 Clinical study
    https://doi.org/10.1016/s0190-9622(99)70485-8
  32. Genillier-Foin, N. and Avenel-Audran, M (2007) 'Purpuric contact dermatitis from Agave americana', Annales de Dermatologie et de Venereologie, 134(5 Pt 1), pp. 477-8. doi:10.1016/s0151-9638(07)89218-0 Clinical study
    https://doi.org/10.1016/s0151-9638(07)89218-0
  1. Camilleri, E., Blundell, R., Baral, B., Karpinski, T.M. et al (2024) 'A brief overview of the medicinal and nutraceutical importance of Inonotus obliquus (chaga) mushrooms', Heliyon, 10(15), pp. e35638. doi:10.1016/j.heliyon.2024.e35638 Traditional / reference
    https://doi.org/10.1016/j.heliyon.2024.e35638
  2. Lu, Y., Jia, Y., Xue, Z., Li, N. et al (2021) 'Recent Developments in Inonotus obliquus (Chaga mushroom) Polysaccharides: Isolation, Structural Characteristics, Biological Activities and Application', Polymers (Basel), 13(9), pp. 1441. doi:10.3390/polym13091441 Traditional / reference
    https://doi.org/10.3390/polym13091441
  3. Kobus, Z., Krzywicka, M., Blicharz-Kania, A., Bosacka, A. et al (2024) 'Impact of Incorporating Dried Chaga Mushroom (Inonotus obliquus) into Gluten-Free Bread on Its Antioxidant and Sensory Characteristics', Molecules, 29(16), pp. 3801. doi:10.3390/molecules29163801 Preclinical
    https://doi.org/10.3390/molecules29163801
  4. Szychowski, K.A., Skora, B., Pomianek, T. and Gminski, J (2020) 'Inonotus obliquus - from folk medicine to clinical use', Journal of Traditional and Complementary Medicine, 11(4), pp. 293-302. doi:10.1016/j.jtcme.2020.08.003 Meta-analysis / review
    https://doi.org/10.1016/j.jtcme.2020.08.003
  5. Javed, S., Mitchell, K., Sidsworth, D., Sellers, S.L., Reutens-Hernandez, J., Massicotte, H.B., Egger, K.N., Lee, C.H. and Payne, G.W (2019) 'Inonotus obliquus attenuates histamine-induced microvascular inflammation', PLoS One, 14(8), pp. e0220776. doi:10.1371/journal.pone.0220776 Preclinical
    https://doi.org/10.1371/journal.pone.0220776
  6. Zou, C., Hou, Z., Bai, M., Guo, R., Lin, B., Wang, X., Huang, X. and Song, S (2020) 'Highly modified steroids from Inonotus obliquus', Organic & Biomolecular Chemistry, 18(20), pp. 3908-3916. doi:10.1039/d0ob00474j Preclinical
    https://doi.org/10.1039/d0ob00474j
  7. Zhong, X.H., Ren, K., Lu, S.J., Yang, S.Y. and Sun, D.Z (2009) 'Progress of research on Inonotus obliquus', Chinese Journal of Integrative Medicine, 15(2), pp. 156-160. doi:10.1007/s11655-009-0156-2 Meta-analysis / review
    https://doi.org/10.1007/s11655-009-0156-2
  8. Burmasova, M.A., Utebaeva, A.A., Sysoeva, E.V. and Sysoeva, M.A (2019) 'Melanins of Inonotus obliquus: bifidogenic and antioxidant properties', Biomolecules, 9(6), pp. 248. doi:10.3390/biom9060248 Preclinical
    https://doi.org/10.3390/biom9060248
  9. Sun, Y., Deng, X., Li, Z., Dong, Y., Jiang, W., Ma, Y., Zhou, W., Zhu, T., Wang, G., Liu, S. and Hu, B (2022) 'Polysaccharide derived from Inonotus obliquus inhibits lipopolysaccharide-induced acute endometritis in mice', American Journal of Translational Research, 14(11), pp. 8332-8342. Preclinical
    https://scholar.google.com/scholar?q=Polysaccharide%20derived%20from%20Inonotus%20obliquus%20inhibits%20lipopolysaccharide-induced%20acute%20endometritis%20in%20mice
  10. Ishfaq, P.M., Mishra, S., Mishra, A., Ahmad, Z., Gayen, S., Jain, S.K., Tripathi, S. and Mishra, S.K (2022) 'Inonotus obliquus aqueous extract prevents histopathological alterations in liver induced by environmental toxicant Microcystin', Current Research in Pharmacology and Drug Discovery, 3, pp. 100118. doi:10.1016/j.crphar.2022.100118 Preclinical
    https://doi.org/10.1016/j.crphar.2022.100118
  11. Peng, A., Liu, S., Fang, L., Zhu, Z., Zhou, Y., Yue, S., Ma, Z., Liu, X., Xue, S., Qiu, Y. and Qi, R (2022) 'Inonotus obliquus and its bioactive compounds alleviate non-alcoholic fatty liver disease via regulating FXR/SHP/SREBP-1c axis', European Journal of Pharmacology, 921, pp. 174841. doi:10.1016/j.ejphar.2022.174841 Preclinical
    https://doi.org/10.1016/j.ejphar.2022.174841
  12. Zhang, Y., Liu, Q., Sun, Y. and Jiang, J (2023) 'Inonotus obliquus sclerotia epidermis were different from internal tissues in compound composition, antioxidant activity, and associated fungi', FEMS Microbiology Letters, 370, pp. fnad126. doi:10.1093/femsle/fnad126 Preclinical
    https://doi.org/10.1093/femsle/fnad126
  13. Yu, S., Lai, Z., Xue, H., Zhu, J., Yue, G., Wang, J. and Jin, L.H (2024) 'Inonotus obliquus aqueous extract inhibits intestinal inflammation and insulin metabolism defects in Drosophila', Toxicology Mechanisms and Methods, 34(9), pp. 970-984. doi:10.1080/15376516.2024.2368795 Preclinical
    https://doi.org/10.1080/15376516.2024.2368795
  14. Wold, C.W. and Christopoulos, P. and Arias, M. and Dzovor, D.E. and Øynebråten, I. and Corthay, A. and Inngjerdingen, K.T (2024) 'Fungal polysaccharides from Inonotus obliquus are agonists for Toll-like receptors and induce macrophage anti-cancer activity', Communications Biology. doi:10.1038/s42003-024-05853-y Preclinical
    https://doi.org/10.1038/s42003-024-05853-y
  15. Li, J. and Qu, C. and Li, F. and Chen, Y. and Zheng, J. and Xiao, Y. and Jin, Q. and Jin, G. and Huang, X. and Jin, D (2021) 'Inonotus obliquus Polysaccharide Ameliorates Azoxymethane/Dextran Sulfate Sodium-Induced Colitis-Associated Cancer in Mice via Activation of the NLRP3 Inflammasome', Frontiers in Pharmacology. doi:10.3389/fphar.2020.621835 Preclinical
    https://doi.org/10.3389/fphar.2020.621835
  16. Wold, C.W. and Gerwick, W.H. and Wangensteen, H. and Inngjerdingen, K.T (2020) 'Bioactive triterpenoids and water-soluble melanin from Inonotus obliquus (Chaga) with immunomodulatory activity', Journal of Functional Foods. doi:10.1016/j.jff.2020.104025 Preclinical
    https://doi.org/10.1016/j.jff.2020.104025
  17. Kim, J. and Yang, S. and Hwang, A.Y. and Cho, H. and Hwang, K.T (2020) 'Composition of Triterpenoids in Inonotus obliquus and Their Anti-Proliferative Activity on Cancer Cell Lines', Molecules. doi:10.3390/molecules25184066 Preclinical
    https://doi.org/10.3390/molecules25184066
  18. Duru, K.C. and Kovaleva, E.G. and Данилова, И.Г. and Bijl, P.V.D (2019) 'The pharmacological potential and possible molecular mechanisms of action of Inonotus obliquus from preclinical studies', Phytotherapy Research. doi:10.1002/ptr.6384 Preclinical
    https://doi.org/10.1002/ptr.6384
  19. Hu, Y. and Teng, C. and Yu, S. and Wang, X. and Liang, J. and Bai, X. and Dong, L. and Song, T. and Yu, M. and Qu, J (2017) 'Inonotus obliquus polysaccharide regulates gut microbiota of chronic pancreatitis in mice', AMB Express. doi:10.1186/s13568-017-0341-1 Preclinical
    https://doi.org/10.1186/s13568-017-0341-1
  20. Chou, Y. and Kan, W. and Chang, C. and Peng, Y. and Wang, H. and Yu, W. and Cheng, Y. and Jhang, Y. and Liu, H. and Chuu, J (2016) 'Renal Protective Effects of Low Molecular Weight of Inonotus obliquus Polysaccharide (LIOP) on HFD/STZ-Induced Nephropathy in Mice', International Journal of Molecular Sciences. doi:10.3390/ijms17091535 Preclinical
    https://doi.org/10.3390/ijms17091535
  21. Arata, S. and Watanabe, J. and Maeda, M. and Yamamoto, M. and Matsuhashi, H. and Mochizuki, M. and Kagami, N. and Honda, K. and Inagaki, M (2016) 'Continuous intake of the Chaga mushroom (Inonotus obliquus) aqueous extract suppresses cancer progression and maintains body temperature in mice', Heliyon. doi:10.1016/j.heliyon.2016.e00111 Preclinical
    https://doi.org/10.1016/j.heliyon.2016.e00111
  22. Lee, K.R. and Lee, J.S. and Kim, Y.R. and Song, I.G. and Hong, E.K (2014) 'Polysaccharide from Inonotus obliquus inhibits migration and invasion in B16-F10 cells by suppressing MMP-2 and MMP-9 via downregulation of NF-κB signaling pathway', Oncology Reports. doi:10.3892/or.2014.3103 Preclinical
    https://doi.org/10.3892/or.2014.3103
  23. Song, F. and Liu, Y. and Kong, X. and Chang, W. and Song, G (2013) 'Progress on Understanding the Anticancer Mechanisms of Medicinal Mushroom: Inonotus Obliquus', Asian Pacific Journal of Cancer Prevention. doi:10.7314/apjcp.2013.14.3.1571 Preclinical
    https://doi.org/10.7314/apjcp.2013.14.3.1571
  24. Gunjima, K. and Tomiyama, R. and Takakura, K. and Yamada, T. and Hashida, K. and Nakamura, Y. and Konishi, T. and Matsugo, S. and Hori, O (2013) '3,4‐Dihydroxybenzalacetone Protects Against Parkinson's Disease‐Related Neurotoxin 6‐OHDA Through Akt/Nrf2/Glutathione Pathway', Journal of Cellular Biochemistry. doi:10.1002/jcb.24643 Preclinical
    https://doi.org/10.1002/jcb.24643
  25. Geng, Y. and Lu, Z. and Huang, W. and Xu, H. and Shi, J. and Xu, Z (2013) 'Bioassay-Guided Isolation of DPP-4 Inhibitory Fractions from Extracts of Submerged Cultured of Inonotus obliquus', Molecules. doi:10.3390/molecules18011150 Preclinical
    https://doi.org/10.3390/molecules18011150
  26. Zhang, L. and Fan, C. and Liu, S. and Zang, Z. and Jiao, L. and Zhang, L (2011) 'Chemical composition and antitumor activity of polysaccharide from Inonotus obliquus', Journal of Medicinal Plants Research. doi:10.5897/jmpr.9000346 Preclinical
    https://doi.org/10.5897/jmpr.9000346
  27. Choi, S. and Hur, S.J. and An, C.S. and Jeon, Y.H. and Jeoung, Y.J. and Bak, J.P. and Lim, B.O (2010) 'Anti-Inflammatory Effects ofInonotus obliquusin Colitis Induced by Dextran Sodium Sulfate', Journal of Biomedicine and Biotechnology. doi:10.1155/2010/943516 Preclinical
    https://doi.org/10.1155/2010/943516
  28. Youn, M. and Kim, J. and Park, S. and Kim, Y. and Kim, S. and Lee, J.S. and Chai, K.Y. and Kim, H. and Cui, M. and So, H.S. and Kim, K. and Park, R (2008) 'Chaga mushroom (Inonotus obliquus ) induces G0/G1 arrest and apoptosis in human hepatoma HepG2 cells', World Journal of Gastroenterology. doi:10.3748/wjg.14.511 Preclinical
    https://doi.org/10.3748/wjg.14.511
  29. Nakajima, Y. and Sato, Y. and Konishi, T (2007) 'Antioxidant Small Phenolic Ingredients in Inonotus obliquus (persoon) Pilat (Chaga)', Chemical and Pharmaceutical Bulletin. doi:10.1248/cpb.55.1222 Preclinical
    https://doi.org/10.1248/cpb.55.1222
  30. Kim, H. and Yoon, D. and Kim, C. and Shrestha, B. and Chang, W. and Lim, S. and Lee, W. and Han, S. and Lee, J. and Lim, M. and Kim, G. and Choi, S. and Song, W.O. and Sung, J. and Hwang, K (2007) 'Ethanol Extract of Inonotus obliquus Inhibits Lipopolysaccharide-Induced Inflammation in RAW 264.7 Macrophage Cells', Journal of Medicinal Food. doi:10.1089/jmf.2006.156 Preclinical
    https://doi.org/10.1089/jmf.2006.156
  31. Mizuno, T. and Zhuang, C. and Abe, K. and Okamoto, H. and Kiho, T. and Ukai, S. and Leclerc, S. and Meijer, L (1999) 'Antitumor and Hypoglycemic Activities of Polysaccharides from the Sclerotia and Mycelia of Inonotus obliquus (Pers.: Fr.) Pil. (Aphyllophoromycetideae)', International journal of medicinal mushrooms. doi:10.1615/intjmedmushr.v1.i4.20 Preclinical
    https://doi.org/10.1615/intjmedmushr.v1.i4.20
  32. Su, L. and Xin, C. and Yang, J. and Dong, L. and Mei, H. and Dai, X. and Wang, Q (2022) 'A polysaccharide from Inonotus obliquus ameliorates intestinal barrier dysfunction in mice with type 2 diabetes mellitus', International Journal of Biological Macromolecules. doi:10.1016/j.ijbiomac.2022.06.071 Preclinical
    https://doi.org/10.1016/j.ijbiomac.2022.06.071
  33. Yang, M. and Hu, D. and Cui, Z. and Li, H. and Man, C. and Jiang, Y (2021) 'Lipid-Lowering Effects of Inonotus obliquus Polysaccharide In Vivo and In Vitro', Foods. doi:10.3390/foods10123085 Preclinical
    https://doi.org/10.3390/foods10123085
  34. Wang, J. and Hu, W. and Li, L. and Huang, X. and Liu, Y. and Wang, D. and Teng, L (2017) 'Antidiabetic activities of polysaccharides separated from Inonotus obliquus via the modulation of oxidative stress in mice with streptozotocin-induced diabetes', PLoS ONE. doi:10.1371/journal.pone.0180476 Preclinical
    https://doi.org/10.1371/journal.pone.0180476
  35. Giridharan, V.V. and Thandavarayan, R.A. and Konishi, T (2011) 'Amelioration of scopolamine induced cognitive dysfunction and oxidative stress by Inonotus obliquus– a medicinal mushroom', Food & Function. doi:10.1039/c1fo10037h Preclinical
    https://doi.org/10.1039/c1fo10037h
  36. Lee, J. and Hyun, C (2014) 'Insulin‐Sensitizing and Beneficial Lipid‐Metabolic Effects of the Water‐Soluble Melanin Complex Extracted from Inonotus obliquus', Phytotherapy Research. doi:10.1002/ptr.5131 Preclinical
    https://doi.org/10.1002/ptr.5131
  37. Kim, Y (2005) 'Immunomodulatory Activity of the Water Extract from Medicinal MushroomInonotus obliquus', Mycobiology. doi:10.4489/myco.2005.33.3.158 Preclinical
    https://doi.org/10.4489/myco.2005.33.3.158
  38. Géry, A., Dubreule, C., André, V., Rioult, J.P., Bouchart, V., Heutte, N., Eldin de Pécoulas, P., Krivomaz, T. and Garon, D (2018) 'Chaga (Inonotus obliquus), a future potential medicinal fungus in oncology? A chemical study and a comparison of the cytotoxicity against human lung adenocarcinoma cells (A549) and human bronchial epithelial cells (BEAS-2B)', 17(3), pp. 832--843. doi:10.1177/1534735418757912 Traditional / reference
    https://doi.org/10.1177/1534735418757912
  39. Royal Botanic Gardens, Kew (n.d.). Available at: https://powo.science.kew.org Traditional / reference
    https://powo.science.kew.org
  40. Shashkina, M.Ya., Shashkin, P.N. and Sergeev, A.V (2006) 'Chemical and medicobiological properties of chaga', 40(10), pp. 560--568. Traditional / reference
    https://scholar.google.com/scholar?q=Chemical%20and%20medicobiological%20properties%20of%20chaga
  41. Duke, J.A (2002) 'Handbook of Medicinal Herbs, Second Edition'. Traditional / reference
    https://scholar.google.com/scholar?q=Handbook%20of%20Medicinal%20Herbs%2C%20Second%20Edition
Aloe Vera monographChaga monographCompare other plants

Generated automatically from the Omnia Sana plant database and its cited sources. For educational purposes only — not medical advice. Always consult a qualified practitioner before using medicinal plants.

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