Plant Comparison

Aloe Vera vs Bistort

A side-by-side comparison of two medicinal plants — every documented constituent, action, use, safety note and cited source, assembled automatically from the Omnia Sana database.

First plant
Second plant
Show:
Plant AAloe VeraAloe veraAsphodelaceaeFull monograph →
Plant BBistortBistorta officinalisPolygonaceaeFull monograph →

At a glance

Aloe Vera and Bistort: they share 7 indicated uses (arthritis / joint pain, bruising, cancer (anticancer research), …); 4 pharmacological actions in common.

Aloe VeraBistort
Constituents33
Pharmacological actions67
Indicated uses1110
Safety notes23
Cited sources3214
Indicated uses
Only Aloe Vera
Back painEczemaHeadachePain (general)
Shared (7)
Arthritis / joint painBruisingCancer (anticancer research)Infection (general)Inflammation (general)Skin irritationWounds
Only Bistort
DiarrhoeaHeavy menstrual bleedingSore throat
Pharmacological actions
Only Aloe Vera
Analgesic (pain relief)Emollient / skin-soothing
Shared (4)
Anti-inflammatoryAnticancer (preclinical)AntimicrobialVulnerary (wound healing)
Only Bistort
AntidiarrhoealAstringentStyptic / haemostatic

Evidence face-off — shared uses

ConditionAloe VeraBistortVerdict
Arthritis / joint pain1/101/10Comparable evidence
Bruising1/101/10Comparable evidence
Cancer (anticancer research)2/102/10Comparable evidence
Infection (general)1/101/10Comparable evidence
Inflammation (general)1/101/10Comparable evidence
Skin irritation1/101/10Comparable evidence
Wounds1/101/10Comparable evidence

Evidence scores (1–10) are computed from the tier of each cited source. “Comparable” means the two scores are within one point. Follow a score to its detailed sources.

Key Constituents

Polysaccharides (acemannan)[1, 13]

Acemannan and other glucomannans are the principal gel polysaccharides, underlying the emollient and wound-healing effects.

PolysaccharidesMucilage
Anthraquinones (aloin, aloe-emodin)[1]

Found mainly in the leaf latex (not the inner gel); responsible for the traditional laxative effect and requiring caution with prolonged use.

Anthraquinones
Enzymes, vitamins and minerals[1]

Minor bioactive enzymes, vitamins (including C and E) and minerals contribute to the antioxidant and skin-conditioning properties of the gel.

Tannins (15-36% of the rhizome: oligomeric proanthocyanidins, gallotannins, catechins)[13, 14]

Very high tannin content is the basis of the strong astringency.

ProanthocyanidinsTanninsCatechins
Phenolic acids and flavonoids[14]

Contribute to antioxidant and antibacterial activity.

Phenolic acidsFlavonoids
Starch and oxalic acid[13]

Other rhizome constituents.

Starch

Pharmacological Actions

Analgesic (pain relief)[13, 14, 15, 16, 17, 18, 19, 20]
Anti-inflammatory[1, 2, 7, 10, 11, 13, 14, 15, 16, 17, 18, 19, 20]
Anticancer (preclinical)[21, 22, 23, 24, 25, 26]

Aloe vera and its anthraquinone aloe-emodin show dose-dependent antiproliferative and pro-apoptotic activity against multiple cancer types in vitro and in vivo (preclinical).

Antimicrobial[1, 3, 9, 11, 13, 14, 15, 16, 17, 18, 19, 20]
Emollient / skin-soothing[4, 13, 14, 15, 16, 17, 18, 19, 20]
Vulnerary (wound healing)[4, 5, 8, 10, 13, 14, 15, 16, 17, 18, 19, 20]
Anti-inflammatory[4, 13, 14]

Anti-inflammatory gargle / mouthwash for inflammation of the mouth and throat (sore throat)

Anticancer (preclinical)[10, 11]

Bistorta officinalis (Polygonum bistorta) rhizome extract, rich in gallotannins and phenolic acids, shows cytotoxic and pro-apoptotic activity against hepatocellular and other cancer cells (preclinical).

Antidiarrhoeal[4, 13, 14]

Astringent for mild diarrhoea (tannins tighten the gut lining and reduce excess secretion)

Antimicrobial[2, 12, 14]

Antibacterial (topical) - GC-MS-characterised extracts showed antibacterial activity

Astringent[7, 13, 14]

Astringent for mild diarrhoea (tannins tighten the gut lining and reduce excess secretion)

Styptic / haemostatic[13, 14]

Vulnerary and styptic for minor wounds (topical)

Vulnerary (wound healing)[13, 14]

Vulnerary and styptic for minor wounds (topical)

Traditional & Indicated Uses

Arthritis / joint pain[13, 14, 15, 16, 17, 18, 19, 20]Traditional · 1/10

inferred from anti-inflammatory action

Evidence: 1
Label: Arthritis / joint pain
Back pain[13, 14, 15, 16, 17, 18, 19, 20]Traditional · 1/10

inferred from analgesic action

Evidence: 1
Label: Back pain
Bruising[13, 14, 15, 16, 17, 18, 19, 20]Traditional · 1/10

inferred from vulnerary action

Evidence: 1
Label: Bruising
Cancer (anticancer research)[21, 22, 23, 24, 25, 26]Traditional · 2/10

Aloe-emodin, an Aloe vera anthraquinone, induces apoptosis and inhibits growth of gastric, oral squamous, hepatocellular, lung (incl. xenograft) and glioblastoma cancer cells, modulating caspases, Bcl-2/Bax, PI3K/Akt and MEK/ERK signalling (preclinical).

Evidence: 2
Label: Cancer (anticancer research)
Eczema[13, 14, 15, 16, 17, 18, 19, 20]Traditional · 1/10

inferred from emollient action

Evidence: 1
Label: Eczema
Headache[13, 14, 15, 16, 17, 18, 19, 20]Traditional · 1/10

inferred from analgesic action

Evidence: 1
Label: Headache
Infection (general)[13, 14, 15, 16, 17, 18, 19, 20]Traditional · 1/10

inferred from antimicrobial action

Evidence: 1
Label: Infection (general)
Inflammation (general)[13, 14, 15, 16, 17, 18, 19, 20]Traditional · 1/10

inferred from anti-inflammatory action

Evidence: 1
Label: Inflammation (general)
Pain (general)[13, 14, 15, 16, 17, 18, 19, 20]Traditional · 1/10
Evidence: 1
Label: Pain (general)
Skin irritation[13, 14, 15, 16, 17, 18, 19, 20]Traditional · 1/10

inferred from anti-inflammatory action

Evidence: 1
Label: Skin irritation
Wounds[13, 14, 15, 16, 17, 18, 19, 20]Traditional · 1/10

inferred from antimicrobial action

Evidence: 1
Label: Wounds
Arthritis / joint pain[13, 14]Traditional · 1/10

inferred from anti-inflammatory action

Evidence: 1
Label: Arthritis / joint pain
Bruising[13, 14]Traditional · 1/10

inferred from vulnerary action

Evidence: 1
Label: Bruising
Cancer (anticancer research)[10, 11]Traditional · 2/10

Polygonum bistorta (Bistorta officinalis) methanol-water and aqueous extracts inhibit hepatocellular carcinoma cells via ROS-induced ER stress and apoptosis (delaying xenograft tumour growth), with phenolic constituents driving the cytotoxicity (preclinical).

Evidence: 2
Label: Cancer (anticancer research)
Diarrhoea[13, 14]Traditional · 1/10

Astringent for mild diarrhoea (tannins tighten the gut lining and reduce excess secretion)

Evidence: 1
Label: Diarrhoea
Heavy menstrual bleeding[13, 14]Traditional · 1/10

inferred from styptic action

Evidence: 1
Label: Heavy menstrual bleeding
Infection (general)[12, 14]Traditional · 1/10

inferred from antimicrobial action

Evidence: 1
Label: Infection (general)
Inflammation (general)[13, 14]Traditional · 1/10

Anti-inflammatory gargle / mouthwash for inflammation of the mouth and throat (sore throat)

Evidence: 1
Label: Inflammation (general)
Skin irritation[13, 14]Traditional · 1/10

inferred from astringent action

Evidence: 1
Label: Skin irritation
Sore throat[13, 14]Traditional · 1/10

Anti-inflammatory gargle / mouthwash for inflammation of the mouth and throat (sore throat)

Evidence: 1
Label: Sore throat
Wounds[13, 14]Traditional · 1/10

Vulnerary and styptic for minor wounds (topical)

Evidence: 1
Label: Wounds

Safety, Cautions & Contraindications

Safety note[13, 14, 15, 16, 17, 18, 19, 20]Caution

Topical use of aloe gel is generally safe for most people. Oral use of aloe latex as a laxative is potentially unsafe with prolonged use due to risk of dehydration, electrolyte imbalance, and potential kidney damage. Aloe latex contains anthraquinone glycosides which may cause abdominal cramping and diarrhea. Not recommended during pregnancy or breastfeeding. May interact with diabetes medications, diuretics, and laxatives. Oral aloe gel at typical doses appears safe short-term but long-term safety is unclear. Allergic reactions possible in sensitive individuals.

Safety note[13, 14, 15, 16, 17, 18, 19, 20, 27]Caution

Duke (2002) reports clinical evidence (score 2/3) supporting aloe gel's use in psoriasis, constipation (in adults), and as a vulnerary. Gel preparations have been clinically validated for peptic ulcers (excluding stress-induced), radiation burns, and skin ulcers. Dose: 1 tablespoon gel three times daily or 50–200 mg dried juice equivalent per day as a laxative. An important safety distinction is made: the gel (inner leaf mucilage) is AHPA Class 1 (safe), while the inner leaf juice or dried latex is Class 2b due to anthraquinone content and is contraindicated in intestinal inflammation, colitis, Crohn's disease, appendicitis, and during menstruation (Duke, 2002).

Safety note[13]Info

Very tannin-rich: high or prolonged intake may cause stomach upset or constipation and can reduce the absorption of iron and some medicines taken at the same time.

Safety note[13]Info

Traditional use only; diarrhoea persisting beyond a few days, or mouth/throat inflammation that does not settle, needs medical assessment.

Safety note[13]Caution

Safety in pregnancy and breastfeeding is not established; avoid medicinal doses.

External Ids

Gbif: 2777724
Powo: urn:lsid:ipni.org:names:530017-1
Wikidata: Q80079
Gbif: 7925535
Wikidata: Q112917

Botanical Description

Succulent, rosette-forming perennial with thick, fleshy, lance-shaped leaves edged with soft, pale teeth, each leaf filled with a clear, slippery, mucilaginous gel beneath a tougher green rind. In favourable conditions it produces a tall flowering spike bearing tubular yellow (sometimes orange) flowers.[1]

Height: Leaves 40-80 cm; flower spike to about 1 m
Habit: Succulent, rosette-forming perennial
Leaves: Thick, fleshy, lance-shaped, edged with soft pale teeth, filled with clear mucilaginous gel
Flowers: Tubular yellow (occasionally orange) flowers on a tall, unbranched or sparsely branched spike
Stem: Very short, often inconspicuous, below the leaf rosette
Root: Shallow, fibrous roots
Fruit: Capsule (rarely produced in cultivation)
Flowering Period: Varies with climate; typically under warm, dry conditions

Perennial herb rising from a thick, twisted, S- or snake-shaped rhizome (giving the names 'bistort' and 'snakeroot'), blackish outside and pink inside. The basal leaves are broadly oval to lance-shaped on long stalks; stem leaves are smaller and stalkless. A single dense, cylindrical spike of small, pale pink flowers is borne atop each unbranched flowering stem.[14]

Height: 30-80 cm
Habit: Erect perennial herb from a twisted rhizome
Leaves: Basal leaves broadly oval to lance-shaped, long-stalked; stem leaves smaller, stalkless
Flowers: Dense, cylindrical spike of small pale pink flowers atop an unbranched stem
Stem: Erect, unbranched, one flower spike per stem
Root: Thick, twisted, S-shaped (snake-like) rhizome, blackish outside, pink inside
Fruit: Small, glossy, three-angled achene
Flowering Period: May-August

Habitat

Believed native to the Arabian Peninsula, and now cultivated and naturalised throughout arid and semi-arid tropical and subtropical regions worldwide as a garden, medicinal and commercial crop.[1]

Grows in damp meadows, pastures, streamsides and mountain grassland on moist, often calcareous soils; native to Europe and temperate Asia, favouring cooler upland regions.[14]

Harvesting

Outer, mature leaves are cut close to the base as needed; the clear inner gel (mucilage) is separated from the outer rind and from the bitter yellow latex (aloin-containing exudate) just under the rind, since the gel and the latex have different uses and safety profiles.[1]

Parts: Leaf
Season: Year-round where climate permits, from mature outer leaves

The rhizome is dug in autumn or early spring, when tannin content is highest, cleaned and dried; aerial parts are gathered in summer while flowering.[14]

Parts: Rhizome (root) and aerial parts
Season: Rhizome in autumn or early spring; aerial parts in summer flowering

Traditional Uses

Aloe vera has an ancient reputation, recorded from ancient Egypt onward, as a topical remedy for burns, wounds and skin inflammation (the 'burn plant' / 'first aid plant'), and the bitter leaf latex has been used traditionally as a stimulant laxative. It remains one of the most widely used topical botanicals for skin care and minor wound healing.[1]

Bistort rhizome, one of the most tannin-rich temperate herbs, has a long European folk history as a powerful astringent for mild diarrhoea, as a gargle for sore throat and mouth inflammation, and topically as a vulnerary and styptic for minor wounds and bleeding; young leaves have also traditionally been eaten as a spring pot-herb ('Easter-ledge pudding').[13, 14]

Preparations

Fresh gel[1]

Clear inner leaf gel applied fresh, or as a stabilised commercial gel, directly to the skin for burns, minor wounds and skin irritation.

Oral juice/gel[1]

Inner leaf gel (latex-free) taken orally, used traditionally for digestive support.

Decoction (rhizome)[14]

Dried rhizome simmered in water as a strongly astringent traditional remedy for diarrhoea, or used as a gargle/mouthwash for sore throat.

Poultice/wash[13]

Crushed rhizome or aerial parts applied externally, or used as a wash, for minor wounds and bleeding.

Dosage

Topical gel[12]

The WHO monograph on Aloe Vera Gel specifies fresh gel, or preparations containing 10-70% fresh gel, applied to the affected skin area. Educational reference only, not a prescription.

Not documented

References

REF-2234, REF-2235, REF-2236, REF-2237, REF-2238, REF-2239, REF-2240, REF-2241, REF-2242, REF-2243, REF-2244
REF-0746, REF-0747, REF-0748, REF-2116, REF-2117, REF-2118, REF-2119, REF-2120, REF-2121, REF-2122, REF-2123, REF-0627

Drug Class Interactions

Safety note[28, 29]Caution
Drug Class: antidiabetics
Mechanism: Aloe vera (taken internally) can lower blood sugar - a meta-analysis found improved fasting glucose in prediabetes and improved HbA1c in type 2 diabetes - so combining it with diabetes medicines may increase the risk of hypoglycaemia; monitor blood glucose.
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-03

Not documented

Lookalikes Review

Outcome: has-lookalikes
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-07
Outcome: none-known
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-07

Dangerous Lookalikes

Safety note[30, 31, 32]Irritant
Dangerous Plant: agave-americana
Confused Part: Fleshy leaves harvested for their soothing gel; agave forms a very similar large rosette of thick, pointed succulent leaves.
Confusion Context: Aloe vera is grown and harvested for the clear soothing gel inside its fleshy leaves. Agave (Agave americana and relatives) forms a very similar rosette of thick, pointed succulent leaves and, as Gardening Know How notes, the two are easily confused if you have not grown both. But agave is not soothing: its sap contains calcium oxalate raphides, steroidal saponins and acrid oils, and peer-reviewed dermatology reports document painful irritant contact dermatitis (even purpura) from agave sap. Applying or ingesting agave sap in mistake for aloe gel can burn the skin, mouth and gut. Because both are common houseplants and garden succulents, this is a realistic mix-up.
Distinguishing Features: Inside the leaf (decisive): snap or cut a leaf. Aloe leaves are soft and filled with clear, slippery gel. Agave leaves are tough and fibrous/stringy with no gel - you cannot easily snap them by hand., Leaf tip and edge: agave leaves end in one hard, sharp terminal spine and often have stiff sharp teeth; aloe has softer, more pliable leaves with soft whitish teeth and no rigid terminal spike., Whole plant over time: aloe flowers repeatedly on a branched stalk and lives on; agave typically flowers only once, on a huge tall stalk, then dies.
Key Test: Cut a leaf. Clear, slippery gel inside a soft leaf = aloe (safe gel). A tough, fibrous leaf with no gel, ending in a hard sharp spine = agave - its sap is an irritant that can burn skin, mouth and gut, so do not use it. When in doubt, do not apply or consume it unless you are certain it is aloe.
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-07

Not documented

References & Sources

  1. Sanchez, M., Gonzalez-Burgos, E., Iglesias, I. and Gomez-Serranillos, M.P (2020) 'Pharmacological update properties of Aloe vera and its major active constituents', Molecules, 25(6), pp. 1324. doi:10.3390/molecules25061324 Meta-analysis / review
    https://doi.org/10.3390/molecules25061324
  2. Kaur, S. and Bains, K (2023) 'Aloe barbadensis Miller (Aloe vera)', International Journal for Vitamin and Nutrition Research, 94(3-4), pp. 308-321. doi:10.1024/0300-9831/a000797 Meta-analysis / review
    https://doi.org/10.1024/0300-9831/a000797
  3. Catalano, A., Ceramella, J., Iacopetta, D., Marra, M., Conforti, F., Lupi, F.R., Gabriele, D., Borges, F. and Sinicropi, M.S (2024) 'Aloe vera - an extensive review focused on recent studies', Foods, 13(13), pp. 2155. doi:10.3390/foods13132155 Meta-analysis / review
    https://doi.org/10.3390/foods13132155
  4. Surjushe, A., Vasani, R. and Saple, D.G (2008) 'Aloe vera: a short review', Indian Journal of Dermatology, 53(4), pp. 163-166. doi:10.4103/0019-5154.44785 Meta-analysis / review
    https://doi.org/10.4103/0019-5154.44785
  5. Liang, J., Cui, L., Li, J., Guan, S., Zhang, K. and Li, J (2020) 'Aloe vera: a medicinal plant used in skin wound healing', Tissue Engineering Part B: Reviews, 27(5), pp. 455-474. doi:10.1089/ten.TEB.2020.0236 Meta-analysis / review
    https://doi.org/10.1089/ten.TEB.2020.0236
  6. Guo, X. and Mei, N (2016) 'Aloe vera: a review of toxicity and adverse clinical effects', Journal of Environmental Science and Health Part C, 34(2), pp. 77-96. doi:10.1080/10590501.2016.1166826 Meta-analysis / review
    https://doi.org/10.1080/10590501.2016.1166826
  7. Boyapati, R., Peeta, J., Dhulipalla, R., Kolaparthy, L., Adurty, C. and Cheruvu, R.N.S (2024) 'Comparative evaluation of the efficacy of probiotic, Aloe vera, povidine-iodine, and chlorhexidine mouthwashes in the treatment of gingival inflammation: a randomized controlled trial', Dental and Medical Problems, 61(2), pp. 181-190. doi:10.17219/dmp/156425 Randomized trial
    https://doi.org/10.17219/dmp/156425
  8. Hekmatpou, D., Mehrabi, F., Rahzani, K. and Aminiyan, A (2019) 'The effect of Aloe vera clinical trials on prevention and healing of skin wound: a systematic review', Iranian Journal of Medical Sciences, 44(1), pp. 1-9. Meta-analysis / review
    https://scholar.google.com/scholar?q=The%20effect%20of%20Aloe%20vera%20clinical%20trials%20on%20prevention%20and%20healing%20of%20skin%20wound%3A%20a%20systematic%20review
  9. Gao, Y., Kuok, K.I., Jin, Y. and Wang, R (2018) 'Biomedical applications of Aloe vera', Critical Reviews in Food Science and Nutrition, 59(sup1), pp. S244-S256. doi:10.1080/10408398.2018.1496320 Meta-analysis / review
    https://doi.org/10.1080/10408398.2018.1496320
  10. Feily, A. and Namazi, M.R (2009) 'Aloe vera in dermatology: a brief review', Giornale Italiano di Dermatologia e Venereologia, 144(1), pp. 85-91. Meta-analysis / review
    https://scholar.google.com/scholar?q=Aloe%20vera%20in%20dermatology%3A%20a%20brief%20review
  11. Sierra-Garcia, G.D., Castro-Rios, R., Gonzalez-Horta, A., Lara-Arias, J. and Chavez-Montes, A (2014) 'Acemannan, an extracted polysaccharide from Aloe vera: a literature review', Natural Product Communications, 9(8), pp. 1217-1221. doi:10.1177/1934578x1400900836 Meta-analysis / review
    https://doi.org/10.1177/1934578x1400900836
  12. World Health Organization (1999) 'Aloe Vera Gel'. Available at: https://iris.who.int/items/6418d8af-5200-4e6b-9bf5-004f3aa62a37 Traditional / reference
    https://iris.who.int/items/6418d8af-5200-4e6b-9bf5-004f3aa62a37
  13. Femenia A, Sánchez ES, Simal S, Rosselló C. Compositional features of polysaccharides from Aloe vera (1999) ';39(2):109-117', 39(2). Traditional / reference
    https://scholar.google.com/scholar?q=%3B39%282%29%3A109-117.
  14. Catalano A, Iacopetta D, Ceramella J, et al. Aloe vera - An extensive review focused on recent studies. Foods. 2024;13 (2024) ';13(13):2155', 13(13). Traditional / reference
    https://scholar.google.com/scholar?q=%3B13%2813%29%3A2155.
  15. Hekmatpou D, Mehrabi F, Rahzani K, Aminiyan A. The effect of Aloe vera clinical trials on prevention and healing of skin wound: A systematic review. Iran J Med Sci. 2019;44 (2019) ';44(1):1-9', 44(1). Available at: https://pmc.ncbi.nlm.nih.gov/articles/PMC6330525/ Traditional / reference
    https://pmc.ncbi.nlm.nih.gov/articles/PMC6330525/
  16. National Center for Complementary and Integrative Health. Aloe vera. NIH. 2020. https://www.nccih.nih.gov/health/aloe-vera (2020) 'https://www.nccih.nih.gov/health/aloe-vera'. Available at: https://www.nccih.nih.gov/health/aloe-vera Traditional / reference
    https://www.nccih.nih.gov/health/aloe-vera
  17. Sahu PK, Giri DD, Singh R, et al. Therapeutic and medicinal uses of Aloe vera: A review. Pharmacol Pharm. 2013;4:599-610 (2013) ';4:599-610'. Traditional / reference
    https://scholar.google.com/scholar?q=%3B4%3A599-610.
  18. Sánchez M, González-Burgos E, Iglesias I, Gómez-Serranillos MP. Pharmacological update properties of Aloe vera and its major active constituents. Molecules. 2020;25 (2020) ';25(6):1324', 25(6). Available at: https://pmc.ncbi.nlm.nih.gov/articles/PMC7144722/ Traditional / reference
    https://pmc.ncbi.nlm.nih.gov/articles/PMC7144722/
  19. Surjushe A, Vasani R, Saple DG. Aloe vera: A short review. Indian J Dermatol. 2008;53 (2008) ';53(4):163-166', 53(4). Available at: https://pmc.ncbi.nlm.nih.gov/articles/PMC2763764/ Traditional / reference
    https://pmc.ncbi.nlm.nih.gov/articles/PMC2763764/
  20. Ulbricht C, Armstrong J, Basch E, et al. An evidence-based systematic review of Aloe vera by the Natural Standard Research Collaboration. J Herb Pharmacother. 2008;7 (2008) ';7(3-4):279-323'. Available at: https://www.ncbi.nlm.nih.gov/books/NBK92765/ Traditional / reference
    https://www.ncbi.nlm.nih.gov/books/NBK92765/
  21. Haroon, N. and Amjad, A. and Maaz, M. and Noman, A.M. and Anees, N. and Muhammad, Z. and Shah, M. and Al Abdulmonem, W (2026) 'Phytochemistry, Bioavailability, and Molecular Mechanisms Underlying Multitarget Anticancer Activity of Aloe vera', Nutrients, 18(12), pp. 2034. doi:10.3390/nu18122034 Preclinical
    https://doi.org/10.3390/nu18122034
  22. Chen, S.-H. and Lin, K.-Y. and Chang, C.-C. and Fang, C.-L. and Lin, C.-P (2007) 'Aloe-emodin-induced apoptosis in human gastric carcinoma cells', Food and Chemical Toxicology, 45(11), pp. 2296-2303. doi:10.1016/j.fct.2007.06.005 Preclinical
    https://doi.org/10.1016/j.fct.2007.06.005
  23. Li, Q. and Wen, J. and Yu, K. and Shu, Y. and He, W. and Chu, H. and Zhang, B. and Ge, C (2018) 'Aloe-emodin induces apoptosis in human oral squamous cell carcinoma SCC15 cells', BMC Complementary and Alternative Medicine, 18(1), pp. 296. doi:10.1186/s12906-018-2353-z Preclinical
    https://doi.org/10.1186/s12906-018-2353-z
  24. Arcella, A. and Sanchez, M (2021) 'Natural substances to potentiate canonical glioblastoma chemotherapy', Journal of Chemotherapy, 33(5), pp. 276-287. doi:10.1080/1120009X.2021.1873633 Preclinical
    https://doi.org/10.1080/1120009X.2021.1873633
  25. Zhu, M. and He, Q. and Wang, Y. and Duan, L. and Rong, K. and Wu, Y. and Ding, Y. and Mi, Y. and Ge, X. and Yang, X. and Yu, Y (2023) 'Exploring the mechanism of aloe-emodin in the treatment of liver cancer through network pharmacology and cell experiments', Frontiers in Pharmacology, 14, pp. 1238841. doi:10.3389/fphar.2023.1238841 Preclinical
    https://doi.org/10.3389/fphar.2023.1238841
  26. Kim, H.J. and Choi, J.W. and Ree, J. and Lim, J.S. and Lee, J. and Kim, J.I. and Thapa, S.B. and Sohng, J.K. and Park, Y.I (2022) 'Aloe emodin 3-O-glucoside inhibits cell growth and migration and induces apoptosis of non-small-cell lung cancer cells via suppressing MEK/ERK and Akt signalling pathways', Life Sciences, 300, pp. 120495. doi:10.1016/j.lfs.2022.120495 Preclinical
    https://doi.org/10.1016/j.lfs.2022.120495
  27. Duke, J.A (2002) 'Handbook of Medicinal Herbs, Second Edition'. Traditional / reference
    https://scholar.google.com/scholar?q=Handbook%20of%20Medicinal%20Herbs%2C%20Second%20Edition
  28. Suksomboon, N., Poolsup, N. and Punthanitisarn, S (2016) 'Effect of Aloe vera on glycaemic control in prediabetes and type 2 diabetes: a systematic review and meta-analysis', Journal of Clinical Pharmacy and Therapeutics, 41(2), pp. 180-188. doi:10.1111/jcpt.12382 Meta-analysis / review
    https://doi.org/10.1111/jcpt.12382
  29. Suksomboon, N., Poolsup, N. and Punthanitisarn, S (2016) 'Effect of Aloe vera on glycaemic control in prediabetes and type 2 diabetes: a systematic review and meta-analysis', Journal of Clinical Pharmacy and Therapeutics, 41(2), pp. 180-188. doi:10.1111/jcpt.12382 Meta-analysis / review
    https://doi.org/10.1111/jcpt.12382
  30. Gardening Know How 'Aloe Vs. Agave Plants: What's The Difference Between Aloe And Agave'. Available at: https://www.gardeningknowhow.com/ornamental/cacti-succulents/scgen/how-to-tell-agave-and-aloe-apart.htm Traditional / reference
    https://www.gardeningknowhow.com/ornamental/cacti-succulents/scgen/how-to-tell-agave-and-aloe-apart.htm
  31. Ricks, M.R. and Vogel, P.S. and Elston, D.M. and Hivnor, C (1999) 'Purpuric agave dermatitis', Journal of the American Academy of Dermatology, 40(2 Pt 2), pp. 356-8. doi:10.1016/s0190-9622(99)70485-8 Clinical study
    https://doi.org/10.1016/s0190-9622(99)70485-8
  32. Genillier-Foin, N. and Avenel-Audran, M (2007) 'Purpuric contact dermatitis from Agave americana', Annales de Dermatologie et de Venereologie, 134(5 Pt 1), pp. 477-8. doi:10.1016/s0151-9638(07)89218-0 Clinical study
    https://doi.org/10.1016/s0151-9638(07)89218-0
  1. Pawłowska, K.A., Hałasa, R., Dudek, M.K., Majdan, M. et al (2020) 'Antibacterial and anti-inflammatory activity of bistort (Bistorta officinalis) aqueous extract and its major components: justification of the usage of the medicinal plant material as a traditional topical agent', Journal of Ethnopharmacology, 260, pp. 113077. doi:10.1016/j.jep.2020.113077 Preclinical
    https://doi.org/10.1016/j.jep.2020.113077
  2. Jovanović, M., Morić, I., Nikolić, B., Pavić, A. et al (2020) 'Anti-Virulence Potential and In Vivo Toxicity of Persicaria maculosa and Bistorta officinalis Extracts', Molecules, 25(8), pp. 1811. doi:10.3390/molecules25081811 Preclinical
    https://doi.org/10.3390/molecules25081811
  3. Duwiejua, M., Zeitlin, I.J., Waterman, P.G. and Gray, A.I (1994) 'Anti-inflammatory activity of Polygonum bistorta, Guaiacum officinale and Hamamelis virginiana in rats', Journal of Pharmacy and Pharmacology, 46(4), pp. 286-290. doi:10.1111/j.2042-7158.1994.tb03795.x Preclinical
    https://doi.org/10.1111/j.2042-7158.1994.tb03795.x
  4. Esmaealzadeh, N., Abdolghaffari, A., Baeeri, M., Hasanpour, M., Iranshahi, M., Santarcangelo, C., Gholami, M. and Bahramsoltani, R (2024) 'Protective effect of freeze-dried extract of Persicaria bistorta Samp. on acetic acid-induced colitis model in rats: involvement of nitric oxide and opioid system', Inflammopharmacology, 32(6), pp. 3845-3861. doi:10.1007/s10787-024-01518-8 Preclinical
    https://doi.org/10.1007/s10787-024-01518-8
  5. Klimczak, U., Wozniak, M., Tomczyk, M. and Granica, S (2017) 'Chemical composition of edible aerial parts of meadow bistort (Persicaria bistorta (L.) Samp.)', Food Chemistry, 230, pp. 281-290. doi:10.1016/j.foodchem.2017.02.128 Preclinical
    https://doi.org/10.1016/j.foodchem.2017.02.128
  6. Manoharan, K.P., Benny, T.K.H. and Yang, D (2005) 'Cycloartane type triterpenoids from the rhizomes of Polygonum bistorta', Phytochemistry, 66(19), pp. 2304-2308. doi:10.1016/j.phytochem.2005.07.008 Preclinical
    https://doi.org/10.1016/j.phytochem.2005.07.008
  7. Liu, X., Hua, H., Liu, J., Chen, F. and Wu, L (2006) 'A new tannin-related compound from the rhizome of Polygonum bistorta L', Journal of Asian Natural Products Research, 8(4), pp. 299-302. doi:10.1080/10286020500034956 Preclinical
    https://doi.org/10.1080/10286020500034956
  8. Yang, W., Qian, Z., Wu, M., Gao, J., Huang, Q., Zou, Y. and Tang, D (2023) 'Online microextraction coupled with HPLC-ABTS for rapid analysis of antioxidants from the root of Polygonum bistorta', Evidence-Based Complementary and Alternative Medicine, 2023, pp. 7496848. doi:10.1155/2023/7496848 Preclinical
    https://doi.org/10.1155/2023/7496848
  9. Bauer, I., Rimbach, G., Nevermann, S., Neuhauser, C., Schwarzinger, B., Schwarzinger, C., Weghuber, J. and Luersen, K (2023) 'In-vitro antidiabetic activity of a Bistorta officinalis Delarbre root extract can not be confirmed in the in-vivo models hen's egg test and Drosophila melanogaster', Journal of Physiology and Pharmacology, 74(1). doi:10.26402/jpp.2023.1.04 Preclinical
    https://doi.org/10.26402/jpp.2023.1.04
  10. Intisar, A., Zhang, L., Luo, H., Kiazolu, J.B., Zhang, R. and Zhang, W (2012) 'Anticancer constituents and cytotoxic activity of methanol-water extract of Polygonum bistorta L', African Journal of Traditional, Complementary and Alternative Medicines, 10(1), pp. 53-59. doi:10.4314/ajtcam.v10i1.9 Preclinical
    https://doi.org/10.4314/ajtcam.v10i1.9
  11. Liu, Y., Weng, Y., Lin, H., Tang, S., Chen, C., Liang, C., Ku, C. and Lin, J (2017) 'Aqueous extract of Polygonum bistorta modulates proteostasis by ROS-induced ER stress in human hepatoma cells', Scientific Reports, 7, pp. 41437. doi:10.1038/srep41437 Preclinical
    https://doi.org/10.1038/srep41437
  12. Khan, S., Arshad, S., Masood, I., Arif, A., Abbas, S., Qureshi, A.W., Parveen, A. and Seemab Ameen, Z (2023) 'GC-MS Analysis of Persicaria bistorta: Uncovering the Molecular Basis of Its Traditional Medicinal Use', Applied Biochemistry and Biotechnology, 196(4), pp. 2270--2288. doi:10.1007/s12010-023-04580-0 Traditional / reference
    https://doi.org/10.1007/s12010-023-04580-0
  13. WebMD (n.d.) 'Bistort: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews'. Available at: https://www.webmd.com/vitamins/ai/ingredientmono-75/bistort Traditional / reference
    https://www.webmd.com/vitamins/ai/ingredientmono-75/bistort
  14. (2020) 'Antibacterial and anti-inflammatory activity of bistort (Bistorta officinalis) aqueous extract and its major components - justification of the usage of the medicinal plant material as a traditional topical agent', Journal of Ethnopharmacology. doi:10.1016/j.jep.2020.113077 Traditional / reference
    https://doi.org/10.1016/j.jep.2020.113077

Generated automatically from the Omnia Sana plant database and its cited sources. For educational purposes only — not medical advice. Always consult a qualified practitioner before using medicinal plants.