Plant Comparison
Aloe Vera vs Greater Burdock
A side-by-side comparison of two medicinal plants — every documented constituent, action, use, safety note and cited source, assembled automatically from the Omnia Sana database.
At a glance
Aloe Vera and Greater Burdock: they share 5 indicated uses (arthritis / joint pain, cancer (anticancer research), eczema, …); 3 pharmacological actions in common.
Evidence face-off — shared uses
| Condition | Aloe Vera | Greater Burdock | Verdict |
|---|---|---|---|
| Arthritis / joint pain | 1/10 | 2/10 | Comparable evidence |
| Cancer (anticancer research) | 2/10 | 2/10 | Comparable evidence |
| Eczema | 1/10 | 2/10 | Comparable evidence |
| Inflammation (general) | 1/10 | 2/10 | Comparable evidence |
| Skin irritation | 1/10 | 2/10 | Comparable evidence |
Evidence scores (1–10) are computed from the tier of each cited source. “Comparable” means the two scores are within one point. Follow a score to its detailed sources.
Key Constituents
Acemannan and other glucomannans are the principal gel polysaccharides, underlying the emollient and wound-healing effects.
Found mainly in the leaf latex (not the inner gel); responsible for the traditional laxative effect and requiring caution with prolonged use.
Minor bioactive enzymes, vitamins (including C and E) and minerals contribute to the antioxidant and skin-conditioning properties of the gel.
Burdock root is a rich source of prebiotic inulin-type fructans (fructooligosaccharides) along with chlorogenic and caffeic acids, the lignans arctiin and arctigenin, cynarine and quercetin, which underlie its antioxidant, anti-inflammatory and gut-supporting activity.
Pharmacological Actions
Aloe vera and its anthraquinone aloe-emodin show dose-dependent antiproliferative and pro-apoptotic activity against multiple cancer types in vitro and in vivo (preclinical).
Burdock (Arctium lappa) extracts and the lignan arctigenin inhibit proliferation and induce apoptosis in colon, breast, lung and gastric cancer cells, attenuate melanoma progression and reduce preneoplastic colon lesions in vivo (preclinical).
Traditional & Indicated Uses
inferred from anti-inflammatory action
inferred from analgesic action
inferred from vulnerary action
Aloe-emodin, an Aloe vera anthraquinone, induces apoptosis and inhibits growth of gastric, oral squamous, hepatocellular, lung (incl. xenograft) and glioblastoma cancer cells, modulating caspases, Bcl-2/Bax, PI3K/Akt and MEK/ERK signalling (preclinical).
inferred from emollient action
inferred from analgesic action
inferred from antimicrobial action
inferred from anti-inflammatory action
inferred from anti-inflammatory action
inferred from anti-inflammatory action
inferred from digestive action
Arctium lappa root reduces diet-induced preneoplastic colon lesions and suppresses melanoma progression; its lignan arctigenin induces apoptosis in colon (HT-29), breast (in vitro/in vivo), lung and gastric cancer cells and chemosensitizes them to doxorubicin (preclinical).
inferred from digestive action
inferred from anti-inflammatory action
Safety, Cautions & Contraindications
Topical use of aloe gel is generally safe for most people. Oral use of aloe latex as a laxative is potentially unsafe with prolonged use due to risk of dehydration, electrolyte imbalance, and potential kidney damage. Aloe latex contains anthraquinone glycosides which may cause abdominal cramping and diarrhea. Not recommended during pregnancy or breastfeeding. May interact with diabetes medications, diuretics, and laxatives. Oral aloe gel at typical doses appears safe short-term but long-term safety is unclear. Allergic reactions possible in sensitive individuals.
Duke (2002) reports clinical evidence (score 2/3) supporting aloe gel's use in psoriasis, constipation (in adults), and as a vulnerary. Gel preparations have been clinically validated for peptic ulcers (excluding stress-induced), radiation burns, and skin ulcers. Dose: 1 tablespoon gel three times daily or 50–200 mg dried juice equivalent per day as a laxative. An important safety distinction is made: the gel (inner leaf mucilage) is AHPA Class 1 (safe), while the inner leaf juice or dried latex is Class 2b due to anthraquinone content and is contraindicated in intestinal inflammation, colitis, Crohn's disease, appendicitis, and during menstruation (Duke, 2002).
Generally safe as a food plant. Allergic reactions are possible in those sensitive to Asteraceae. Avoid in pregnancy due to uterine-stimulating effects reported in animal studies. The burs (seed heads) can cause mechanical irritation of skin and eyes on contact. Not recommended in biliary obstruction.
Duke (2002) rates burdock as +++ and notes antibacterial, antimutagenic, antitumor, choleretic, diuretic, and prebiotic (bifidogenic) activities at the experimental level (score 1). The root is rich in inulin (a prebiotic fructooligosaccharide), which promotes growth of beneficial intestinal bacteria. Dose: 1–2 g dried root in tea three times daily, or 2–4 ml of tincture. Duke notes burdock's general safety, though it belongs to the Asteraceae family and can trigger reactions in sensitive individuals. It should be distinguished from belladonna and similar plants, which resemble it in early growth (Duke, 2002).
External Ids
Botanical Description
Succulent, rosette-forming perennial with thick, fleshy, lance-shaped leaves edged with soft, pale teeth, each leaf filled with a clear, slippery, mucilaginous gel beneath a tougher green rind. In favourable conditions it produces a tall flowering spike bearing tubular yellow (sometimes orange) flowers.[1]
Robust biennial herb forming a large rosette of huge, heart-shaped (rhubarb-like), long-stalked leaves, dark green above and whitish-woolly beneath, in its first year. In the second year it sends up a tall, branching, grooved flowering stem bearing purple thistle-like flower heads enclosed in a globe of stiff, hooked bracts that ripen into the familiar clinging burrs.[1, 2]
Habitat
Believed native to the Arabian Peninsula, and now cultivated and naturalised throughout arid and semi-arid tropical and subtropical regions worldwide as a garden, medicinal and commercial crop.[1]
A common weed of disturbed ground, waste places, roadsides, field margins and riverbanks on rich, moist soils; native to Europe and temperate Asia and naturalised in North America and elsewhere.[2]
Harvesting
Outer, mature leaves are cut close to the base as needed; the clear inner gel (mucilage) is separated from the outer rind and from the bitter yellow latex (aloin-containing exudate) just under the rind, since the gel and the latex have different uses and safety profiles.[1]
The root is dug at the end of the first growing season (autumn) or early in the second spring, before the flowering stem develops, when it is at its most tender and richest in inulin; leaves are picked through the first year, and the seed/fruit is collected from the dried burrs in the second autumn. Careful identification against deadly nightshade, whose root can resemble burdock, is essential before digging.[11]
Traditional Uses
Aloe vera has an ancient reputation, recorded from ancient Egypt onward, as a topical remedy for burns, wounds and skin inflammation (the 'burn plant' / 'first aid plant'), and the bitter leaf latex has been used traditionally as a stimulant laxative. It remains one of the most widely used topical botanicals for skin care and minor wound healing.[1]
Preparations
Dried or fresh root simmered in water as a traditional alterative and digestive decoction.
Tincture of the dried root, ethanol 45% V/V or 25% V/V, 8-12 ml three times daily per the EU herbal monograph. The monograph states the ethanol strength but no drug-extract ratio, so no 1:5 ratio is claimed here. Educational reference only, not a prescription.
Fresh root peeled and cooked as a root vegetable (gobo), continuing the traditional food-medicine use.
Dosage
The WHO monograph on Aloe Vera Gel specifies fresh gel, or preparations containing 10-70% fresh gel, applied to the affected skin area. Educational reference only, not a prescription.
The EU herbal monograph on Arctium lappa L., radix gives, for adults and elderly, a single dose of 2-6 g of the comminuted root as an infusion, 3 times daily; a powdered herbal substance at 350 mg 3-5 times daily, a liquid extract at 2-8 mL 3 times daily and a soft extract at 0.2 g per dose (1-2 g daily) are also listed. Not recommended under 18 years, and a practitioner should be consulted if symptoms persist beyond 2 weeks. Educational reference only, not a prescription.
The EU herbal monograph gives 8-12 mL three times daily, for tinctures in either 45% V/V or 25% V/V ethanol, in adults and elderly. Educational reference only, not a prescription.
References
Drug Class Interactions
Not documented
Lookalikes Review
Dangerous Lookalikes
References & Sources
- Sanchez, M., Gonzalez-Burgos, E., Iglesias, I. and Gomez-Serranillos, M.P (2020) 'Pharmacological update properties of Aloe vera and its major active constituents', Molecules, 25(6), pp. 1324. doi:10.3390/molecules25061324 Meta-analysis / review
https://doi.org/10.3390/molecules25061324 - Kaur, S. and Bains, K (2023) 'Aloe barbadensis Miller (Aloe vera)', International Journal for Vitamin and Nutrition Research, 94(3-4), pp. 308-321. doi:10.1024/0300-9831/a000797 Meta-analysis / review
https://doi.org/10.1024/0300-9831/a000797 - Catalano, A., Ceramella, J., Iacopetta, D., Marra, M., Conforti, F., Lupi, F.R., Gabriele, D., Borges, F. and Sinicropi, M.S (2024) 'Aloe vera - an extensive review focused on recent studies', Foods, 13(13), pp. 2155. doi:10.3390/foods13132155 Meta-analysis / review
https://doi.org/10.3390/foods13132155 - Surjushe, A., Vasani, R. and Saple, D.G (2008) 'Aloe vera: a short review', Indian Journal of Dermatology, 53(4), pp. 163-166. doi:10.4103/0019-5154.44785 Meta-analysis / review
https://doi.org/10.4103/0019-5154.44785 - Liang, J., Cui, L., Li, J., Guan, S., Zhang, K. and Li, J (2020) 'Aloe vera: a medicinal plant used in skin wound healing', Tissue Engineering Part B: Reviews, 27(5), pp. 455-474. doi:10.1089/ten.TEB.2020.0236 Meta-analysis / review
https://doi.org/10.1089/ten.TEB.2020.0236 - Guo, X. and Mei, N (2016) 'Aloe vera: a review of toxicity and adverse clinical effects', Journal of Environmental Science and Health Part C, 34(2), pp. 77-96. doi:10.1080/10590501.2016.1166826 Meta-analysis / review
https://doi.org/10.1080/10590501.2016.1166826 - Boyapati, R., Peeta, J., Dhulipalla, R., Kolaparthy, L., Adurty, C. and Cheruvu, R.N.S (2024) 'Comparative evaluation of the efficacy of probiotic, Aloe vera, povidine-iodine, and chlorhexidine mouthwashes in the treatment of gingival inflammation: a randomized controlled trial', Dental and Medical Problems, 61(2), pp. 181-190. doi:10.17219/dmp/156425 Randomized trial
https://doi.org/10.17219/dmp/156425 - Hekmatpou, D., Mehrabi, F., Rahzani, K. and Aminiyan, A (2019) 'The effect of Aloe vera clinical trials on prevention and healing of skin wound: a systematic review', Iranian Journal of Medical Sciences, 44(1), pp. 1-9. Meta-analysis / review
https://scholar.google.com/scholar?q=The%20effect%20of%20Aloe%20vera%20clinical%20trials%20on%20prevention%20and%20healing%20of%20skin%20wound%3A%20a%20systematic%20review - Gao, Y., Kuok, K.I., Jin, Y. and Wang, R (2018) 'Biomedical applications of Aloe vera', Critical Reviews in Food Science and Nutrition, 59(sup1), pp. S244-S256. doi:10.1080/10408398.2018.1496320 Meta-analysis / review
https://doi.org/10.1080/10408398.2018.1496320 - Feily, A. and Namazi, M.R (2009) 'Aloe vera in dermatology: a brief review', Giornale Italiano di Dermatologia e Venereologia, 144(1), pp. 85-91. Meta-analysis / review
https://scholar.google.com/scholar?q=Aloe%20vera%20in%20dermatology%3A%20a%20brief%20review - Sierra-Garcia, G.D., Castro-Rios, R., Gonzalez-Horta, A., Lara-Arias, J. and Chavez-Montes, A (2014) 'Acemannan, an extracted polysaccharide from Aloe vera: a literature review', Natural Product Communications, 9(8), pp. 1217-1221. doi:10.1177/1934578x1400900836 Meta-analysis / review
https://doi.org/10.1177/1934578x1400900836 - World Health Organization (1999) 'Aloe Vera Gel'. Available at: https://iris.who.int/items/6418d8af-5200-4e6b-9bf5-004f3aa62a37 Traditional / reference
https://iris.who.int/items/6418d8af-5200-4e6b-9bf5-004f3aa62a37 - Femenia A, Sánchez ES, Simal S, Rosselló C. Compositional features of polysaccharides from Aloe vera (1999) ';39(2):109-117', 39(2). Traditional / reference
https://scholar.google.com/scholar?q=%3B39%282%29%3A109-117. - Catalano A, Iacopetta D, Ceramella J, et al. Aloe vera - An extensive review focused on recent studies. Foods. 2024;13 (2024) ';13(13):2155', 13(13). Traditional / reference
https://scholar.google.com/scholar?q=%3B13%2813%29%3A2155. - Hekmatpou D, Mehrabi F, Rahzani K, Aminiyan A. The effect of Aloe vera clinical trials on prevention and healing of skin wound: A systematic review. Iran J Med Sci. 2019;44 (2019) ';44(1):1-9', 44(1). Available at: https://pmc.ncbi.nlm.nih.gov/articles/PMC6330525/ Traditional / reference
https://pmc.ncbi.nlm.nih.gov/articles/PMC6330525/ - National Center for Complementary and Integrative Health. Aloe vera. NIH. 2020. https://www.nccih.nih.gov/health/aloe-vera (2020) 'https://www.nccih.nih.gov/health/aloe-vera'. Available at: https://www.nccih.nih.gov/health/aloe-vera Traditional / reference
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https://scholar.google.com/scholar?q=%3B4%3A599-610. - Sánchez M, González-Burgos E, Iglesias I, Gómez-Serranillos MP. Pharmacological update properties of Aloe vera and its major active constituents. Molecules. 2020;25 (2020) ';25(6):1324', 25(6). Available at: https://pmc.ncbi.nlm.nih.gov/articles/PMC7144722/ Traditional / reference
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Generated automatically from the Omnia Sana plant database and its cited sources. For educational purposes only — not medical advice. Always consult a qualified practitioner before using medicinal plants.