Plant Comparison
Agrimony vs Chia
A side-by-side comparison of two medicinal plants — every documented constituent, action, use, safety note and cited source, assembled automatically from the Omnia Sana database.
At a glance
Agrimony and Chia: they share 5 indicated uses (arthritis / joint pain, bloating, indigestion, …); 3 pharmacological actions in common.
Evidence face-off — shared uses
| Condition | Agrimony | Chia | Verdict |
|---|---|---|---|
| Arthritis / joint pain | 2/10 | 5/10 | Stronger for Chia |
| Bloating | 2/10 | 5/10 | Stronger for Chia |
| Indigestion | 2/10 | 5/10 | Stronger for Chia |
| Inflammation (general) | 2/10 | 5/10 | Stronger for Chia |
| Skin irritation | 1/10 | 5/10 | Stronger for Chia |
Evidence scores (1–10) are computed from the tier of each cited source. “Comparable” means the two scores are within one point. Follow a score to its detailed sources.
Key Constituents
Responsible for the characteristic astringency.
Antioxidant and anti-inflammatory constituents.
The dominant fatty acid of chia oil, one of the richest plant sources of omega-3 known.
Responsible for the seed's characteristic gel-forming property when soaked.
Contribute to the seed's antioxidant activity.
Chia is a complete plant protein source and exceptionally high in dietary fibre.
Pharmacological Actions
Anti-inflammatory gargle (mild inflammation of the mouth and throat / sore throat)
Agrimonia eupatoria ethanolic extract is cytotoxic to breast, colon, lung and cervical cancer cells and inhibits the PI3K/Akt/mTOR pathway (preclinical/in silico).
Traditional & Indicated Uses
inferred from bitter-tonic action
inferred from anti-inflammatory action
Agrimonia eupatoria ethanolic extract shows dose-dependent cytotoxicity against MCF-7 (breast), HT-29 (colon), A549 (lung) and HeLa (cervical) cancer cells and inhibits the PI3K/Akt/mTOR/COX-2/MMP-2 axis (preclinical).
Astringent (relief of mild diarrhoea)
Mild bitter digestive tonic (indigestion)
Anti-inflammatory gargle (mild inflammation of the mouth and throat / sore throat); Vulnerary (minor skin inflammation and small superficial wounds, topical)
inferred from astringent action
Anti-inflammatory gargle (mild inflammation of the mouth and throat / sore throat)
inferred from anti-inflammatory action
inferred from anti-inflammatory action
Safety, Cautions & Contraindications
Traditional-use indication only: if diarrhoea persists longer than 3-4 days, or symptoms of mouth/throat inflammation persist beyond about a week, a doctor should be consulted.
Use during pregnancy and breastfeeding is not recommended, as safety has not been established.
Never swallow a spoon of dry chia seeds and “chase” with water. They can swell fast and (rarely) cause a blockage, especially if someone already has swallowing problems (American College of Gastroenterology, 2014) Blood pressure / diabetes meds: if you’re on medication for blood pressure or blood sugar, chia as a major daily addition may slightly add to the effect for some people—monitor and talk to your clinician (Saadh et al., 2024) (Pam et al., 2024).
External Ids
Botanical Description
Slender, downy perennial herb with a basal rosette of pinnately compound leaves and a single, unbranched, upright flowering stem. The leaflets are toothed, alternating large and small, and silvery-downy beneath. Small, five-petalled, bright yellow flowers are borne closely along a slender terminal spike (raceme), opening a few at a time from the base upwards, giving the old name 'church steeples'. After flowering, small bristly, hooked burrs form that cling to clothing and animal fur for dispersal.[13, 14]
Annual herb (Lamiaceae), 1-1.5 m tall, with square stems. Leaves are opposite, ovate to oblong with a toothed margin. Small purple to white, two-lipped flowers are borne in dense terminal spikes, followed by small oval seeds (grey-brown, mottled, or occasionally white) - the part used.[1]
Habitat
Native to central and southern Mexico and Guatemala, historically a staple crop of Aztec and Mayan agriculture; now cultivated commercially in warm subtropical and tropical regions worldwide (notably South America and Australia) as a food crop.[1]
Harvesting
The flowering aerial parts are cut in summer, at the start of flowering, and dried promptly in a warm, airy, shaded place.[13]
Seed heads are harvested once dry, typically in autumn, and threshed to release the small seeds.[1]
Traditional Uses
Agrimony has a long folk history as an astringent remedy for mild diarrhoea, as a gargle for sore throats and mild mouth/throat inflammation, and as a mild bitter digestive tonic; it has also been applied topically to minor wounds and skin inflammation. It is officially recognised in the European Union herbal monograph for traditional use in mild diarrhoea and mild inflammation of the mouth or throat.[13, 14]
Chia seed has an ancient Mesoamerican food-medicine tradition as an energy-sustaining staple food for Aztec warriors and runners. Its modern popularity centres on its dense nutrient profile - fibre, omega-3 (alpha-linolenic acid) fatty acids, protein and antioxidants - studied for metabolic, cardiovascular and digestive support.[1]
Preparations
Eaten whole, ground, or soaked to form a gel (due to the seed's high mucilage content), stirred into food or drinks.
Dosage
The EU herbal monograph gives 1.5-4 g of the comminuted herb in 250 mL (or less) of boiling water as an infusion, 2-3 times daily, in adolescents, adults and elderly. As a gargle for mild oral or throat inflammation, 1.5 g in 150 mL of boiling water 2-4 times daily, or a decoction of 3-4.5 g in 250 mL 2-3 times daily. Educational reference only, not a prescription.
The EU herbal monograph gives 1-4 mL three times daily (orally, or as a gargle for oral and throat use). Educational reference only, not a prescription.
References
Lookalikes Review
References & Sources
- Malheiros, J., Simoes, D.M., Figueirinha, A., Cotrim, M.D. and Fonseca, D.A (2022) 'Agrimonia eupatoria L.: An integrative perspective on ethnomedicinal use, phenolic composition and pharmacological activity', Journal of Ethnopharmacology, pp. 2022. doi:10.1016/j.jep.2022.115498 Preclinical
https://doi.org/10.1016/j.jep.2022.115498 - Paluch, Z., Biriczova, L., Pallag, G., Carvalheiro Marques, E., Vargova, N. and Kmonickova, E (2020) 'The therapeutic effects of Agrimonia eupatoria L', Physiological Research, pp. S555--S571. doi:10.33549/physiolres.934641 Preclinical
https://doi.org/10.33549/physiolres.934641 - Kuczmannova, A., Balazova, A., Racanska, E., Kamenikova, M., Fialova, S., Majernik, J., Nagy, M., Gal, P. and Mucaji, P (2016) 'Agrimonia eupatoria L. and Cynara cardunculus L. water infusions: comparison of anti-diabetic activities', Molecules, 21(5), pp. 564. doi:10.3390/molecules21050564 Preclinical
https://doi.org/10.3390/molecules21050564 - Huzio, N., Grytsyk, A., Raal, A., Grytsyk, L. and Koshovyi, O (2022) 'Phytochemical and pharmacological research in Agrimonia eupatoria L. herb extract with anti-inflammatory and hepatoprotective properties', Plants, 11(18), pp. 2371. doi:10.3390/plants11182371 Preclinical
https://doi.org/10.3390/plants11182371 - Correia, H.S., Batista, M.T. and Dinis, T.C.P (2007) 'The activity of an extract and fraction of Agrimonia eupatoria L. against reactive species', BioFactors, 29(2-3), pp. 91-104. doi:10.1002/biof.552029209 Preclinical
https://doi.org/10.1002/biof.552029209 - Granica, S., Kluge, H., Horn, G., Matkowski, A. and Kiss, A.K (2015) 'The phytochemical investigation of Agrimonia eupatoria L. and Agrimonia procera Wallr. as valid sources of Agrimoniae herba - the pharmacopoeial plant material', Journal of Pharmaceutical and Biomedical Analysis, 114, pp. 272-279. doi:10.1016/j.jpba.2015.05.027 Preclinical
https://doi.org/10.1016/j.jpba.2015.05.027 - Tsirigotis-Maniecka, M., Zaczynska, E., Czarny, A., Jadczyk, P., Uminska-Wasiluk, B., Gancarz, R. and Pawlaczyk-Graja, I (2023) 'Antioxidant and protective effects of the polyphenolic glycoconjugate from Agrimonia eupatoria L. herb in the prevention of inflammation in human cells', Journal of Functional Biomaterials, 14(4), pp. 182. doi:10.3390/jfb14040182 Preclinical
https://doi.org/10.3390/jfb14040182 - Kwon, D.H., Kwon, H.Y., Kim, H.J., Chang, E.J., Kim, M.B., Yoon, S.K., Song, E.Y., Yoon, D.Y., Lee, Y.H., Choi, I.S. and Choi, Y.K (2005) 'Inhibition of hepatitis B virus by an aqueous extract of Agrimonia eupatoria L', Phytotherapy Research, 19(4), pp. 355-358. doi:10.1002/ptr.1689 Preclinical
https://doi.org/10.1002/ptr.1689 - Karlinska, E., Romanowska, B. and Kosmala, M (2021) 'The aerial parts of Agrimonia procera Wallr. and Agrimonia eupatoria L. as a source of polyphenols, and especially agrimoniin and flavonoids', Molecules, 26(24), pp. 7706. doi:10.3390/molecules26247706 Preclinical
https://doi.org/10.3390/molecules26247706 - Kuczmannova, A., Gal, P., Varinska, L., Treml, J., Kovac, I., Novotny, M., Vasilenko, T., Dall'Acqua, S., Nagy, M. and Mucaji, P (2015) 'Agrimonia eupatoria L. and Cynara cardunculus L. water infusions: phenolic profile and comparison of antioxidant activities', Molecules, 20(11), pp. 20538-20550. doi:10.3390/molecules201119715 Preclinical
https://doi.org/10.3390/molecules201119715 - Ivanova, D., Vankova, D. and Nashar, M (2013) 'Agrimonia eupatoria tea consumption in relation to markers of inflammation, oxidative status and lipid metabolism in healthy subjects', Archives of Physiology and Biochemistry, 119(1), pp. 32-37. doi:10.3109/13813455.2012.729844 Clinical study
https://doi.org/10.3109/13813455.2012.729844 - Venskutonis, P.R., Skemaite, M. and Ragazinskiene, O (2007) 'Radical scavenging capacity of Agrimonia eupatoria and Agrimonia procera', Fitoterapia, 78(2), pp. 166-168. doi:10.1016/j.fitote.2006.10.002 Preclinical
https://doi.org/10.1016/j.fitote.2006.10.002 - European Medicines Agency (HMPC) (2015) 'European Union herbal monograph on Agrimonia eupatoria L., herba (Agrimoniae herba)'. Available at: https://www.ema.europa.eu/en/medicines/herbal/agrimoniae-herba Traditional / reference
https://www.ema.europa.eu/en/medicines/herbal/agrimoniae-herba - (2022) 'Agrimonia eupatoria L.: An integrative perspective on ethnomedicinal use, phenolic composition and pharmacological activity', Journal of Ethnopharmacology. doi:10.1016/j.jep.2022.115498 Traditional / reference
https://doi.org/10.1016/j.jep.2022.115498 - Herbal Reality (n.d.) 'Agrimony (Agrimonia eupatoria): Benefits, Uses, Safety'. Available at: https://www.herbalreality.com/herb/agrimony/ Traditional / reference
https://www.herbalreality.com/herb/agrimony/ - Lee, K.H. and Rhee, K.H (2016) 'Anti-nociceptive effect of Agrimonia eupatoria extract on a cisplatin-induced neuropathic model', African Journal of Traditional, Complementary and Alternative Medicines, 13(5), pp. 139--144. doi:10.21010/ajtcam.v13i5.18 Preclinical
https://doi.org/10.21010/ajtcam.v13i5.18 - Ginovyan, M. and Gevorgyan, S. and Javrushyan, H. and Kusznierewicz, B. and Koss-Mikolajczyk, I. and Sahakyan, N. and Bartoszek, A. and Avtandilyan, N (2026) 'Inhibition of the PI3K signaling pathway in cancer cells by Agrimonia eupatoria L. ethanolic extract: identification of tricoumaroyl spermidine as a potential PI3K inhibitor', BMC Complementary Medicine and Therapies, 26(1), pp. 41. doi:10.1186/s12906-025-05231-z Preclinical
https://doi.org/10.1186/s12906-025-05231-z - Shareef, S.H., Asaad, N.K., Gheni, N.A., Fisal, D.N., Shakir Agha, N.F., Ali, R.T. and Abdulla, M.A (2025) 'Agrimonia eupatoria leaf extract attenuates alcohol-induced oxidative stress, ulcer and alleviates stomach damage in rats', Food Science and Nutrition, 13(11). doi:10.1002/fsn3.71203 Preclinical
https://doi.org/10.1002/fsn3.71203 - Vasilenko, T., Kovac, I., Slezak, M., Durkac, J., Perzelova, V., Coma, M. and others (2022) 'Agrimonia eupatoria L. aqueous extract improves skin wound healing: an in vitro study in fibroblasts and keratinocytes and in vivo study in rats', In Vivo, 36(3), pp. 1236--1244. doi:10.21873/invivo.12822 Preclinical
https://doi.org/10.21873/invivo.12822
- Khalid, W., Arshad, M.S., Aziz, A., Rahim, M.A. and others (2023) 'Chia seeds (Salvia hispanica L.): A therapeutic weapon in metabolic disorders', Food Science & Nutrition, 11(1), pp. 3-16. doi:10.1002/fsn3.3035 Meta-analysis / review
https://doi.org/10.1002/fsn3.3035 - Enes, B.N., Moreira, L.P.D., Silva, B.P., Grancieri, M. and others (2020) 'Chia seed (Salvia hispanica L.) effects and their molecular mechanisms on unbalanced diet experimental studies: A systematic review', Journal of Food Science, 85(2), pp. 226-239. doi:10.1111/1750-3841.15003 Meta-analysis / review
https://doi.org/10.1111/1750-3841.15003 - Silva, L.A., Verneque, B.J.F., Mota, A.P.L. and Duarte, C.K (2021) 'Chia seed (Salvia hispanica L.) consumption and lipid profile: a systematic review and meta-analysis', Food & Function, 12(19), pp. 8835-8849. doi:10.1039/d1fo01287h Meta-analysis / review
https://doi.org/10.1039/d1fo01287h - Valdivia-Lopez, M.A. and Tecante, A (2015) 'Chia (Salvia hispanica): A Review of Native Mexican Seed and its Nutritional and Functional Properties', Advances in Food and Nutrition Research, 75, pp. 53-75. doi:10.1016/bs.afnr.2015.06.002 Meta-analysis / review
https://doi.org/10.1016/bs.afnr.2015.06.002 - Teoh, S.L., Lai, N.M., Vanichkulpitak, P., Vuksan, V. and others (2018) 'Clinical evidence on dietary supplementation with chia seed (Salvia hispanica L.): a systematic review and meta-analysis', Nutrition Reviews, 76(4), pp. 219-242. doi:10.1093/nutrit/nux071 Meta-analysis / review
https://doi.org/10.1093/nutrit/nux071 - de Souza Ferreira, C., de Sousa Fomes, L.F., da Silva, G.E. and Rosa, G (2015) 'Effect of chia seed (Salvia hispanica L.) consumption on cardiovascular risk factors in humans: a systematic review', Nutricion Hospitalaria, 32(5), pp. 1909-1918. doi:10.3305/nh.2015.32.5.9394 Meta-analysis / review
https://doi.org/10.3305/nh.2015.32.5.9394 - Knez Hrncic, M., Ivanovski, M., Cor, D. and Knez, Z (2019) 'Chia Seeds (Salvia hispanica L.): An Overview-Phytochemical Profile, Isolation Methods, and Application', Molecules, 25(1), pp. 11. doi:10.3390/molecules25010011 Meta-analysis / review
https://doi.org/10.3390/molecules25010011 - Oliva, M.E., Ferreira, M.D.R., Vega Joubert, M.B. and D'Alessandro, M.E (2020) 'Salvia hispanica L. (chia) seed promotes body fat depletion and modulates adipocyte lipid handling in sucrose-rich diet-fed rats', Food Research International, 139, pp. 109842. doi:10.1016/j.foodres.2020.109842 Preclinical
https://doi.org/10.1016/j.foodres.2020.109842 - Vega Joubert, M.B., Degrave, V., Ingaramo, P., Oliva, M.E. and others (2022) 'Salvia hispanica L. (chia) seed improves liver inflammation and endothelial dysfunction in an experimental model of metabolic syndrome', Food & Function, 13(21), pp. 11249-11261. doi:10.1039/d2fo02216h Preclinical
https://doi.org/10.1039/d2fo02216h - Grancieri, M., Martino, H.S.D. and Gonzalez de Mejia, E (2019) 'Chia Seed (Salvia hispanica L.) as a Source of Proteins and Bioactive Peptides with Health Benefits: A Review', Comprehensive Reviews in Food Science and Food Safety, 18(2), pp. 480-499. doi:10.1111/1541-4337.12423 Meta-analysis / review
https://doi.org/10.1111/1541-4337.12423 - Royal Botanic Gardens, Kew (n.d.). Available at: https://powo.science.kew.org Traditional / reference
https://powo.science.kew.org - Vuksan, V., Jenkins, A.L., Dias, A.G., Lee, A.S., Jovanovski, E., Rogovik, A.L. and Hanna, A (2010) 'Reduction in postprandial glucose excursion and prolongation of satiety: possible explanation of the long-term effects of whole grain Salba (Salvia hispanica L.)', 64(4), pp. 436--438. doi:10.1038/ejcn.2009.159 Randomized trial
https://doi.org/10.1038/ejcn.2009.159 - Chandalia, M., Garg, A., Lutjohann, D., von Bergmann, K., Grundy, S.M. and Brinkley, L.J (2000) 'Beneficial effects of high dietary fiber intake in patients with type 2 diabetes mellitus', 342(19), pp. 1392--1398. doi:10.1056/nejm200005113421903 Randomized trial
https://doi.org/10.1056/nejm200005113421903 - Duke, J.A (2002) 'Handbook of Medicinal Herbs, Second Edition'. Traditional / reference
https://scholar.google.com/scholar?q=Handbook%20of%20Medicinal%20Herbs%2C%20Second%20Edition
Generated automatically from the Omnia Sana plant database and its cited sources. For educational purposes only — not medical advice. Always consult a qualified practitioner before using medicinal plants.