Plant Comparison
Agrimony vs Mallow
A side-by-side comparison of two medicinal plants — every documented constituent, action, use, safety note and cited source, assembled automatically from the Omnia Sana database.
At a glance
Agrimony and Mallow: they share 7 indicated uses (arthritis / joint pain, bruising, cancer (anticancer research), …); 4 pharmacological actions in common.
Evidence face-off — shared uses
| Condition | Agrimony | Mallow | Verdict |
|---|---|---|---|
| Arthritis / joint pain | 2/10 | 1/10 | Comparable evidence |
| Bruising | 2/10 | 1/10 | Comparable evidence |
| Cancer (anticancer research) | 2/10 | 7/10 | Stronger for Mallow |
| Inflammation (general) | 2/10 | 2/10 | Comparable evidence |
| Skin irritation | 1/10 | 2/10 | Comparable evidence |
| Sore throat | 2/10 | 1/10 | Comparable evidence |
| Wounds | 2/10 | 5/10 | Stronger for Mallow |
Evidence scores (1–10) are computed from the tier of each cited source. “Comparable” means the two scores are within one point. Follow a score to its detailed sources.
Key Constituents
Responsible for the characteristic astringency.
Antioxidant and anti-inflammatory constituents.
The high mucilage content gives the demulcent, soothing action.
The blue-purple pigments and antioxidant constituents.
Phenolic constituents associated with antioxidant and reported antiproliferative (anticancer) activity in cell studies.
Pharmacological Actions
Anti-inflammatory gargle (mild inflammation of the mouth and throat / sore throat)
Agrimonia eupatoria ethanolic extract is cytotoxic to breast, colon, lung and cervical cancer cells and inhibits the PI3K/Akt/mTOR pathway (preclinical/in silico).
Anti-inflammatory, analgesic and wound-healing (preclinical)
Antibacterial / antimicrobial (methanolic leaf extracts; the naphthoquinone Malvone A)
Demulcent for irritation of the mouth or throat and associated dry cough (soothing mucilage); Mild laxative for occasional constipation (mucilage; traditional)
Mild laxative for occasional constipation (mucilage; traditional)
Traditional & Indicated Uses
inferred from bitter-tonic action
inferred from anti-inflammatory action
Agrimonia eupatoria ethanolic extract shows dose-dependent cytotoxicity against MCF-7 (breast), HT-29 (colon), A549 (lung) and HeLa (cervical) cancer cells and inhibits the PI3K/Akt/mTOR/COX-2/MMP-2 axis (preclinical).
Astringent (relief of mild diarrhoea)
Mild bitter digestive tonic (indigestion)
Anti-inflammatory gargle (mild inflammation of the mouth and throat / sore throat); Vulnerary (minor skin inflammation and small superficial wounds, topical)
inferred from astringent action
Anti-inflammatory gargle (mild inflammation of the mouth and throat / sore throat)
inferred from anti-inflammatory action
inferred from anticancer action
Mild laxative for occasional constipation (mucilage; traditional)
Demulcent for irritation of the mouth or throat and associated dry cough (soothing mucilage)
inferred from antimicrobial action
inferred from anti-inflammatory action
inferred from analgesic action
Soothes irritated and inflamed skin and mucous membranes
Safety, Cautions & Contraindications
Traditional-use indication only: if diarrhoea persists longer than 3-4 days, or symptoms of mouth/throat inflammation persist beyond about a week, a doctor should be consulted.
Use during pregnancy and breastfeeding is not recommended, as safety has not been established.
Generally very well tolerated. Irritation of the mouth/throat or a cough that persists beyond about a week, or is accompanied by fever or breathlessness, needs medical assessment.
Use in pregnancy and breastfeeding is not recommended in the absence of adequate data.
External Ids
Botanical Description
Slender, downy perennial herb with a basal rosette of pinnately compound leaves and a single, unbranched, upright flowering stem. The leaflets are toothed, alternating large and small, and silvery-downy beneath. Small, five-petalled, bright yellow flowers are borne closely along a slender terminal spike (raceme), opening a few at a time from the base upwards, giving the old name 'church steeples'. After flowering, small bristly, hooked burrs form that cling to clothing and animal fur for dispersal.[13, 14]
Biennial or short-lived perennial herb, 30-120 cm tall, with erect or sprawling, branched, often reddish stems. Leaves are alternate, long-stalked and palmately lobed with 5-7 shallow rounded lobes and toothed margins. Flowers are pink-purple with darker veining, with five notch-tipped petals borne in small axillary clusters. The fruit is a flattened, disc-shaped schizocarp ('cheese') that splits into a ring of small single-seeded nutlets.[2]
Habitat
Common on roadsides, waste ground, hedgebanks and field margins across Europe, North Africa and temperate Asia, and widely naturalised elsewhere; tolerates a wide range of soils, favouring sunny, disturbed, nitrogen-rich sites.[2]
Harvesting
The flowering aerial parts are cut in summer, at the start of flowering, and dried promptly in a warm, airy, shaded place.[13]
Leaves and flowers are gathered during the flowering period (summer) and dried quickly out of direct sun to preserve their mucilage content; fresh material can also be used directly for infusions or poultices.[11]
Traditional Uses
Agrimony has a long folk history as an astringent remedy for mild diarrhoea, as a gargle for sore throats and mild mouth/throat inflammation, and as a mild bitter digestive tonic; it has also been applied topically to minor wounds and skin inflammation. It is officially recognised in the European Union herbal monograph for traditional use in mild diarrhoea and mild inflammation of the mouth or throat.[13, 14]
Mallow leaf and flower have a long ethnobotanical history across Europe as a demulcent for irritated mucous membranes - soothing coughs, sore throat and mouth irritation - and for occasional constipation and skin irritation, reflecting the mucilage-rich leaf and flower. Modern phytochemical and pharmacological work confirms antioxidant, anti-inflammatory, antimicrobial and wound-healing activity of its extracts.[2, 11]
Preparations
Dosage
The EU herbal monograph gives 1.5-4 g of the comminuted herb in 250 mL (or less) of boiling water as an infusion, 2-3 times daily, in adolescents, adults and elderly. As a gargle for mild oral or throat inflammation, 1.5 g in 150 mL of boiling water 2-4 times daily, or a decoction of 3-4.5 g in 250 mL 2-3 times daily. Educational reference only, not a prescription.
The EU herbal monograph gives 1-4 mL three times daily (orally, or as a gargle for oral and throat use). Educational reference only, not a prescription.
EMA herbal-monograph guidance suggests roughly 1.5-2 g of dried leaf or flower per cup, taken as an infusion up to 3 times daily. Educational reference only, not a prescription.
References
Lookalikes Review
References & Sources
- Malheiros, J., Simoes, D.M., Figueirinha, A., Cotrim, M.D. and Fonseca, D.A (2022) 'Agrimonia eupatoria L.: An integrative perspective on ethnomedicinal use, phenolic composition and pharmacological activity', Journal of Ethnopharmacology, pp. 2022. doi:10.1016/j.jep.2022.115498 Preclinical
https://doi.org/10.1016/j.jep.2022.115498 - Paluch, Z., Biriczova, L., Pallag, G., Carvalheiro Marques, E., Vargova, N. and Kmonickova, E (2020) 'The therapeutic effects of Agrimonia eupatoria L', Physiological Research, pp. S555--S571. doi:10.33549/physiolres.934641 Preclinical
https://doi.org/10.33549/physiolres.934641 - Kuczmannova, A., Balazova, A., Racanska, E., Kamenikova, M., Fialova, S., Majernik, J., Nagy, M., Gal, P. and Mucaji, P (2016) 'Agrimonia eupatoria L. and Cynara cardunculus L. water infusions: comparison of anti-diabetic activities', Molecules, 21(5), pp. 564. doi:10.3390/molecules21050564 Preclinical
https://doi.org/10.3390/molecules21050564 - Huzio, N., Grytsyk, A., Raal, A., Grytsyk, L. and Koshovyi, O (2022) 'Phytochemical and pharmacological research in Agrimonia eupatoria L. herb extract with anti-inflammatory and hepatoprotective properties', Plants, 11(18), pp. 2371. doi:10.3390/plants11182371 Preclinical
https://doi.org/10.3390/plants11182371 - Correia, H.S., Batista, M.T. and Dinis, T.C.P (2007) 'The activity of an extract and fraction of Agrimonia eupatoria L. against reactive species', BioFactors, 29(2-3), pp. 91-104. doi:10.1002/biof.552029209 Preclinical
https://doi.org/10.1002/biof.552029209 - Granica, S., Kluge, H., Horn, G., Matkowski, A. and Kiss, A.K (2015) 'The phytochemical investigation of Agrimonia eupatoria L. and Agrimonia procera Wallr. as valid sources of Agrimoniae herba - the pharmacopoeial plant material', Journal of Pharmaceutical and Biomedical Analysis, 114, pp. 272-279. doi:10.1016/j.jpba.2015.05.027 Preclinical
https://doi.org/10.1016/j.jpba.2015.05.027 - Tsirigotis-Maniecka, M., Zaczynska, E., Czarny, A., Jadczyk, P., Uminska-Wasiluk, B., Gancarz, R. and Pawlaczyk-Graja, I (2023) 'Antioxidant and protective effects of the polyphenolic glycoconjugate from Agrimonia eupatoria L. herb in the prevention of inflammation in human cells', Journal of Functional Biomaterials, 14(4), pp. 182. doi:10.3390/jfb14040182 Preclinical
https://doi.org/10.3390/jfb14040182 - Kwon, D.H., Kwon, H.Y., Kim, H.J., Chang, E.J., Kim, M.B., Yoon, S.K., Song, E.Y., Yoon, D.Y., Lee, Y.H., Choi, I.S. and Choi, Y.K (2005) 'Inhibition of hepatitis B virus by an aqueous extract of Agrimonia eupatoria L', Phytotherapy Research, 19(4), pp. 355-358. doi:10.1002/ptr.1689 Preclinical
https://doi.org/10.1002/ptr.1689 - Karlinska, E., Romanowska, B. and Kosmala, M (2021) 'The aerial parts of Agrimonia procera Wallr. and Agrimonia eupatoria L. as a source of polyphenols, and especially agrimoniin and flavonoids', Molecules, 26(24), pp. 7706. doi:10.3390/molecules26247706 Preclinical
https://doi.org/10.3390/molecules26247706 - Kuczmannova, A., Gal, P., Varinska, L., Treml, J., Kovac, I., Novotny, M., Vasilenko, T., Dall'Acqua, S., Nagy, M. and Mucaji, P (2015) 'Agrimonia eupatoria L. and Cynara cardunculus L. water infusions: phenolic profile and comparison of antioxidant activities', Molecules, 20(11), pp. 20538-20550. doi:10.3390/molecules201119715 Preclinical
https://doi.org/10.3390/molecules201119715 - Ivanova, D., Vankova, D. and Nashar, M (2013) 'Agrimonia eupatoria tea consumption in relation to markers of inflammation, oxidative status and lipid metabolism in healthy subjects', Archives of Physiology and Biochemistry, 119(1), pp. 32-37. doi:10.3109/13813455.2012.729844 Clinical study
https://doi.org/10.3109/13813455.2012.729844 - Venskutonis, P.R., Skemaite, M. and Ragazinskiene, O (2007) 'Radical scavenging capacity of Agrimonia eupatoria and Agrimonia procera', Fitoterapia, 78(2), pp. 166-168. doi:10.1016/j.fitote.2006.10.002 Preclinical
https://doi.org/10.1016/j.fitote.2006.10.002 - European Medicines Agency (HMPC) (2015) 'European Union herbal monograph on Agrimonia eupatoria L., herba (Agrimoniae herba)'. Available at: https://www.ema.europa.eu/en/medicines/herbal/agrimoniae-herba Traditional / reference
https://www.ema.europa.eu/en/medicines/herbal/agrimoniae-herba - (2022) 'Agrimonia eupatoria L.: An integrative perspective on ethnomedicinal use, phenolic composition and pharmacological activity', Journal of Ethnopharmacology. doi:10.1016/j.jep.2022.115498 Traditional / reference
https://doi.org/10.1016/j.jep.2022.115498 - Herbal Reality (n.d.) 'Agrimony (Agrimonia eupatoria): Benefits, Uses, Safety'. Available at: https://www.herbalreality.com/herb/agrimony/ Traditional / reference
https://www.herbalreality.com/herb/agrimony/ - Lee, K.H. and Rhee, K.H (2016) 'Anti-nociceptive effect of Agrimonia eupatoria extract on a cisplatin-induced neuropathic model', African Journal of Traditional, Complementary and Alternative Medicines, 13(5), pp. 139--144. doi:10.21010/ajtcam.v13i5.18 Preclinical
https://doi.org/10.21010/ajtcam.v13i5.18 - Ginovyan, M. and Gevorgyan, S. and Javrushyan, H. and Kusznierewicz, B. and Koss-Mikolajczyk, I. and Sahakyan, N. and Bartoszek, A. and Avtandilyan, N (2026) 'Inhibition of the PI3K signaling pathway in cancer cells by Agrimonia eupatoria L. ethanolic extract: identification of tricoumaroyl spermidine as a potential PI3K inhibitor', BMC Complementary Medicine and Therapies, 26(1), pp. 41. doi:10.1186/s12906-025-05231-z Preclinical
https://doi.org/10.1186/s12906-025-05231-z - Shareef, S.H., Asaad, N.K., Gheni, N.A., Fisal, D.N., Shakir Agha, N.F., Ali, R.T. and Abdulla, M.A (2025) 'Agrimonia eupatoria leaf extract attenuates alcohol-induced oxidative stress, ulcer and alleviates stomach damage in rats', Food Science and Nutrition, 13(11). doi:10.1002/fsn3.71203 Preclinical
https://doi.org/10.1002/fsn3.71203 - Vasilenko, T., Kovac, I., Slezak, M., Durkac, J., Perzelova, V., Coma, M. and others (2022) 'Agrimonia eupatoria L. aqueous extract improves skin wound healing: an in vitro study in fibroblasts and keratinocytes and in vivo study in rats', In Vivo, 36(3), pp. 1236--1244. doi:10.21873/invivo.12822 Preclinical
https://doi.org/10.21873/invivo.12822
- Mousavi, S.M., Hashemi, S.A., Behbudi, G., Mazraedoost, S. and others (2021) 'A Review on Health Benefits of Malva sylvestris L. Nutritional Compounds for Metabolites, Antioxidants, and Anti-Inflammatory, Anticancer, and Antimicrobial Applications', Evidence-Based Complementary and Alternative Medicine, 2021, pp. 5548404. doi:10.1155/2021/5548404 Meta-analysis / review
https://doi.org/10.1155/2021/5548404 - Gasparetto, J.C., Martins, C.A., Hayashi, S.S., Otuky, M.F. and others (2012) 'Ethnobotanical and scientific aspects of Malva sylvestris L.: a millennial herbal medicine', Journal of Pharmacy and Pharmacology, 64(2), pp. 172-189. doi:10.1111/j.2042-7158.2011.01383.x Meta-analysis / review
https://doi.org/10.1111/j.2042-7158.2011.01383.x - Wu, Y., Qiu, A., Yang, Z., Wu, J. and others (2019) 'Malva sylvestris extract alleviates the astrogliosis and inflammatory stress in LPS-induced depression mice', Journal of Neuroimmunology, 336, pp. 577029. doi:10.1016/j.jneuroim.2019.577029 Preclinical
https://doi.org/10.1016/j.jneuroim.2019.577029 - Ben Saad, A., Rjeibi, I., Brahmi, D., Smida, A. and others (2016) 'Malva sylvestris extract protects upon lithium carbonate-induced kidney damages in male rat', Biomedicine & Pharmacotherapy, 84, pp. 1099-1107. doi:10.1016/j.biopha.2016.10.026 Preclinical
https://doi.org/10.1016/j.biopha.2016.10.026 - Zuo, H., Li, Y., Cui, Y. and An, Y (2017) 'Cardioprotective effect of Malva sylvestris L. in myocardial ischemic/reperfused rats', Biomedicine & Pharmacotherapy, 95, pp. 679-684. doi:10.1016/j.biopha.2017.08.111 Preclinical
https://doi.org/10.1016/j.biopha.2017.08.111 - Benso, B., Rosalen, P.L., Alencar, S.M. and Murata, R.M (2015) 'Malva sylvestris Inhibits Inflammatory Response in Oral Human Cells. An In Vitro Infection Model', PLoS One, 10(10), pp. e0140331. doi:10.1371/journal.pone.0140331 Preclinical
https://doi.org/10.1371/journal.pone.0140331 - Prudente, A.S., Sponchiado, G., Mendes, D.A.G.B., Soley, B.S. and others (2017) 'Pre-clinical efficacy assessment of Malva sylvestris on chronic skin inflammation', Biomedicine & Pharmacotherapy, 93, pp. 852-860. doi:10.1016/j.biopha.2017.06.083 Preclinical
https://doi.org/10.1016/j.biopha.2017.06.083 - Mohaghegh, Z., Golfakhrabadi, F., Faal Siahkal, S., Dastoorpoor, M. and others (2022) 'The Effect of Malva sylvestris Cream on Episiotomy Pain and Healing: A Randomized Controlled Clinical Trial', International Journal of Community Based Nursing and Midwifery, 10(4), pp. 248-258. doi:10.30476/IJCBNM.2022.95772.2082 Randomized trial
https://doi.org/10.30476/IJCBNM.2022.95772.2082 - Areesanan, A., Nicolay, S., Keller, M., Zimmermann-Klemd, A.M. and others (2023) 'Potential benefits of Malva sylvestris in dry-eye disease pathology in vitro based on antioxidant, wound-healing and anti-inflammatory properties', Biomedicine & Pharmacotherapy, 168, pp. 115782. doi:10.1016/j.biopha.2023.115782 Preclinical
https://doi.org/10.1016/j.biopha.2023.115782 - Martins, C.A., Weffort-Santos, A.M., Gasparetto, J.C., Trindade, A.C. and others (2014) 'Malva sylvestris L. extract suppresses desferrioxamine-induced PGE2 and PGD2 release in differentiated U937 cells', Biomedical Chromatography, 28(7), pp. 986-993. doi:10.1002/bmc.3106 Preclinical
https://doi.org/10.1002/bmc.3106 - European Medicines Agency (HMPC) (n.d.) 'European Union herbal monograph on Malva sylvestris L., folium and flos (Malvae folium / Malvae sylvestris flos)'. Available at: https://www.ema.europa.eu/en/medicines/herbal/malvae-folium Traditional / reference
https://www.ema.europa.eu/en/medicines/herbal/malvae-folium - Paul, Z.A. and Malla, A.T. and Dar, M.A. and Masoodi, M.H (2024) 'Phytochemistry and Pharmacological Activity of Malva sylvestris L.: A Detailed Insight', Combinatorial Chemistry & High Throughput Screening, 27(16), pp. 2309--2322. doi:10.2174/0113862073269336231009110313 Traditional / reference
https://doi.org/10.2174/0113862073269336231009110313 - Batiha, G.E. and Tene, S.T. and Teibo, J.O. and Shaheen, H.M. and Oluwatoba, O.S. and Teibo, T.K.A. and Al-Kuraishy, H.M. and Al-Garbee, A.I. and Alexiou, A. and Papadakis, M (2022) 'The phytochemical profiling, pharmacological activities, and safety of Malva sylvestris: a review', Naunyn-Schmiedeberg's Archives of Pharmacology, 396(3), pp. 421--440. doi:10.1007/s00210-022-02329-w Traditional / reference
https://doi.org/10.1007/s00210-022-02329-w
Generated automatically from the Omnia Sana plant database and its cited sources. For educational purposes only — not medical advice. Always consult a qualified practitioner before using medicinal plants.