Guarana (Paullinia cupana) Stimulates Mitochondrial Biogenesis in Mice Fed High-Fat Diet

Abstract

In high-fat-diet-fed mice, guarana (Paullinia cupana) reduced body weight, adipose depots, glycaemia and triglycerides, increased oxygen consumption and energy expenditure, and stimulated mitochondrial biogenesis in muscle and brown adipose tissue, demonstrating that guarana increases energy metabolism and helps control weight gain.