Lactuca L. Extract Enhances Sleep Duration Through Upregulation of Adenosine A1 Receptor and GABA-A Receptor Subunits in Pentobarbital-Injected Mice
Abstract
A Lactuca (lettuce) extract was investigated in pentobarbital-induced sleep in mice. The extract significantly reduced sleep latency and increased sleep duration, and increased the expression of the adenosine A1 receptor and several GABA-A receptor subunits in the brain, indicating it could be used to develop natural products that improve sleep quality and duration — a mechanism relevant to wild lettuce's traditional sedative use.
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How to cite
Lee, M., Park, J., Cho, W., Jun, Y. et al (2024) 'Lactuca L. Extract Enhances Sleep Duration Through Upregulation of Adenosine A1 Receptor and GABA-A Receptor Subunits in Pentobarbital-Injected Mice', Journal of Medicinal Food, 27(7), pp. 661-668. doi:10.1089/jmf.2023.K.0250
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