St. John's wort (Hypericum perforatum) and depression: what happens to the neurotransmitter systems?
Abstract
St. John's wort (Hypericum perforatum) contains bioactive molecules including hyperforin and hypericin and has therapeutic effects on depression and other mood/psychiatric disorders. This review discusses the role of St John's wort in modulating depression with respect to neurotransmitter systems in the brain, concluding that it induces complex, sometimes inconsistent effects on neurotransmitter levels, with glutamate and acetylcholine highlighted for future study.
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How to cite
Kholghi, G., Arjmandi-Rad, S., Zarrindast, M.R. and Vaseghi, S (2022) 'St. John's wort (Hypericum perforatum) and depression: what happens to the neurotransmitter systems?', Naunyn-Schmiedeberg's Archives of Pharmacology, 395(6), pp. 629-642. doi:10.1007/s00210-022-02229-z
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