Sea buckthorn extract mitigates chronic obstructive pulmonary disease by suppression of ferroptosis via scavenging ROS and blocking p53/MAPK pathways
Abstract
Sea buckthorn (Hippophae rhamnoides), a traditional Tibetan medicinal herb, exhibits protective effects against respiratory diseases. In bronchial epithelial cells and an LPS/elastase-induced COPD mouse model, sea buckthorn extract suppressed ferroptosis by directly scavenging reactive oxygen species and blocking the p53 and MAPK pathways, reducing lipid peroxides, cytokines and chemokines, supporting its clinical application in COPD.
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How to cite
Liu, L., Wen, T., Xiao, Y., Chen, H. et al (2024) 'Sea buckthorn extract mitigates chronic obstructive pulmonary disease by suppression of ferroptosis via scavenging ROS and blocking p53/MAPK pathways', Journal of Ethnopharmacology, 336, pp. 118726. doi:10.1016/j.jep.2024.118726
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