Hamamelitannin from Hamamelis virginiana Attenuates Ethanol-Induced Oxidative and Inflammatory Responses in Danio rerio Larvae
Abstract
Hamamelitannin, a gallotannin from Hamamelis virginiana bark, was evaluated against ethanol-induced inflammation in a zebrafish larvae model of alcoholic liver disorder. Co-treatment normalised antioxidant enzymes (SOD, CAT, GPx), reduced reactive oxygen species, lipid peroxidation and macrophage infiltration, and downregulated inflammatory mediators (iNOS, TNF-alpha, COX-2, IL-1beta), indicating hepatoprotective and anti-inflammatory properties of the witch hazel tannin.
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How to cite
Janarthanam, V.A., Rajan, P.S.S., Panda, S.P., Panigrahy, U.P. et al (2025) 'Hamamelitannin from Hamamelis virginiana Attenuates Ethanol-Induced Oxidative and Inflammatory Responses in Danio rerio Larvae', Molecular Biotechnology, 68(5), pp. 2369-2385. doi:10.1007/s12033-025-01502-9
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