Ganoderma lucidum spore powder and derived triterpenes attenuate atherosclerosis and aortic calcification by stimulating ABCA1/G1-mediated macrophage cholesterol efflux and inactivating RUNX2-mediated VSMC osteogenesis
Abstract
Ganoderma lucidum spore powder (GLSP) and its triterpenes (ganoderic acids A, B, C6, G and ganodermanontriol) attenuated plaque area and aortic calcification in atherosclerotic mice by improving ABCA1/G1-mediated macrophage cholesterol efflux, reducing foam cells and inflammation, and inactivating RUNX2-mediated osteogenesis in vascular smooth muscle cells, suggesting reishi as a candidate against atherosclerosis and vascular calcification.
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How to cite
Zheng, G., Zhao, Y., Li, Z., Hua, Y. et al (2023) 'Ganoderma lucidum spore powder and derived triterpenes attenuate atherosclerosis and aortic calcification by stimulating ABCA1/G1-mediated macrophage cholesterol efflux and inactivating RUNX2-mediated VSMC osteogenesis', Theranostics, 13(4), pp. 1325-1341. doi:10.7150/thno.80250
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