In Vitro Biotransformation and Anti-Inflammatory Activity of Constituents and Metabolites of Filipendula ulmaria
Abstract
Filipendula ulmaria (meadowsweet) is widely used in phytotherapy against inflammatory diseases. An in vitro gastrointestinal biotransformation model showed glycosylated flavonoids (rutin, spiraeoside) decrease while aglycones (quercetin, apigenin, naringenin, kaempferol) increase in the colon; both the genuine and metabolised extracts inhibited COX-1 more than COX-2, indicating the anti-inflammatory activity arises from an additive/synergistic effect of constituents and gut-microbiota metabolites.
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How to cite
Van der Auwera, A., Peeters, L., Foubert, K., Piazza, S. et al (2023) 'In Vitro Biotransformation and Anti-Inflammatory Activity of Constituents and Metabolites of Filipendula ulmaria', Pharmaceutics, 15(4), pp. 1291. doi:10.3390/pharmaceutics15041291
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