Saffron essential oil ameliorates CUMS-induced depression-like behavior in mice via the MAPK-CREB1-BDNF signaling pathway

Chen, Z., Gu, J., Lin, S., Xu, Z. et al. · Journal of Ethnopharmacology · 2022

Preclinical

Abstract

Saffron (Crocus sativus) has a long history in the treatment of depression. In mice exposed to chronic unpredictable mild stress, inhaled saffron essential oil improved depression-like behaviors, raised serum 5-HT, dopamine, BDNF and GABA, and ameliorated hippocampal neuronal damage, acting mainly through upregulation of the MAPK-CREB1-BDNF signaling pathway.

Referenced for these plants

How to cite

Chen, Z., Gu, J., Lin, S., Xu, Z. et al (2022) 'Saffron essential oil ameliorates CUMS-induced depression-like behavior in mice via the MAPK-CREB1-BDNF signaling pathway', Journal of Ethnopharmacology, 300, pp. 115719. doi:10.1016/j.jep.2022.115719

This reference is part of the evidence base for the Omnia Sana plant database. Source links open the original publication; Omnia Sana does not host third-party content.