Analgesic effect of Centaurium erythraea and molecular docking investigation of the major component swertiamarin
Abstract
The ethanolic extract of the flowering aerial parts of Centaurium erythraea, characterised by the iridoid swertiamarin, was tested in pain models in Wistar rats. It significantly decreased acetic-acid-induced writhing (peripheral analgesia) and elevated the basal reaction time in the hot plate test (central analgesia); molecular docking showed good binding of swertiamarin to cyclooxygenase-2, justifying the traditional use of centaury as an analgesic remedy.
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How to cite
Chabane, S., Boudjelal, A., Bouaziz-Terrachet, S., Spinozzi, E. et al (2023) 'Analgesic effect of Centaurium erythraea and molecular docking investigation of the major component swertiamarin', Natural Product Research, 38(24), pp. 4511-4517. doi:10.1080/14786419.2023.2278160
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