Total biosynthesis of the medicinal triterpenoid saponin astragalosides
Abstract
Astragalus membranaceus has been used in traditional Chinese medicine for over 2,000 years, and its major active triterpenoid saponins, astragalosides, have multiple health benefits. A chromosome-level genome assembly enabled discovery of a triterpenoid biosynthetic gene cluster and elucidation of the complete astragaloside biosynthetic pathway (selective hydroxylation, epoxidation and glycosylation by P450s, a dioxygenase and glycosyltransferases), and heterologous production of astragaloside IV, providing a foundation for addressing sourcing of these medicinal saponins.
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How to cite
Xu, B., Huang, J.P., Peng, G., Cao, W., Liu, Z. et al (2024) 'Total biosynthesis of the medicinal triterpenoid saponin astragalosides', Nature Plants, 10(11), pp. 1826-1837. doi:10.1038/s41477-024-01827-4
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