An androstane bioside and 3'-thiazolidinone derivatives of doubly-linked cardenolide glycosides from the roots of Asclepias tuberosa

Abstract

Steroidal compounds in the roots of Asclepias tuberosa were investigated. A new androstane glycoside termed ascandroside was isolated, along with doubly-linked cardenolide glycosides including 3'-spiro-linked thiazolidinone and S-oxythiazolidinone derivatives of delta5-calotropin, and nine glycosides of uzarigenin, coroglaucigenin and corotoxigenin. The work characterises the cardenolide (cardiac glycoside) chemistry that underlies the pharmacology and toxicity of pleurisy root.