Astragalus polysaccharides alleviate DSS-induced ulcerative colitis in mice by restoring SCFA production and regulating Th17/Treg cell homeostasis in a microbiota-dependent manner
Abstract
Astragalus polysaccharides (APS) ameliorated colonic injury and gut microbiota disruption and restored intestinal immune homeostasis in mice with DSS-induced colitis. APS increased SCFA-producing microbiota and SCFA production, dually inhibited NF-kappaB activation via the TLR4 and HDAC3 pathways and improved the Th17/Treg balance, indicating APS is a promising prebiotic agent that ameliorates colitis in a gut-microbiota-dependent manner.
Referenced for these plants
How to cite
Zhang, Y., Ji, W., Qin, H., Chen, Z., Zhou, Y. et al (2024) 'Astragalus polysaccharides alleviate DSS-induced ulcerative colitis in mice by restoring SCFA production and regulating Th17/Treg cell homeostasis in a microbiota-dependent manner', Carbohydrate Polymers, 349, pp. 122829. doi:10.1016/j.carbpol.2024.122829
This reference is part of the evidence base for the Omnia Sana plant database. Source links open the original publication; Omnia Sana does not host third-party content.