Immune regulation and inflammation inhibition of Arctium lappa L. polysaccharides by TLR4/NF-κB signaling pathway in cells
Abstract
Arctium lappa L. polysaccharides (ALP) are important active ingredients of burdock roots. A crude polysaccharide was extracted and purified to 99% purity, and its immunomodulatory activity and intestinal anti-inflammatory effects were investigated in LPS-induced RAW264.7 macrophages and IL-1beta-induced Caco-2 colon cells. ALP possessed both antioxidant and anti-inflammatory effects, inhibiting pro-inflammatory cytokines (IL-8, IL-6, IL-1beta, TNF-alpha) by down-regulating the TLR4/NF-kappaB signaling pathway, indicating burdock as a source of bioactive polysaccharides for immune support.
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How to cite
Zeng, F., Li, Y., Zhang, X., Shen, L., Zhao, X. et al (2023) 'Immune regulation and inflammation inhibition of Arctium lappa L. polysaccharides by TLR4/NF-κB signaling pathway in cells', International Journal of Biological Macromolecules, 254, pp. 127700. doi:10.1016/j.ijbiomac.2023.127700
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