The Neuroprotective Role of Acorus calamus in Developmental and Histopathological Changes in Autism-Induced Wistar Rats
Abstract
A rat model of autism was created by administering sodium valproate in pregnancy. Autism-induced pups treated with an ethanolic extract of Acorus calamus (200 mg/kg) were compared with untreated controls. Neurodegenerative changes were well appreciated in the untreated autism group, with significant reduction in frontal-cortex neurons and cerebellar Purkinje cells, whereas the A. calamus-treated group did not show significant alteration, suggesting A. calamus in the early postnatal period protects brain morphology against autism pathology.
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How to cite
Ukkirapandian, K., Kayalvizhi, E., Udaykumar, K.P., Kandhi, S. and Muthulakshmi, R (2022) 'The Neuroprotective Role of Acorus calamus in Developmental and Histopathological Changes in Autism-Induced Wistar Rats', Cureus, 14(9), pp. e29717. doi:10.7759/cureus.29717
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