A non-polar fraction of Saponaria officinalis L. acted as a TLR4/MD2 complex antagonist and inhibited TLR4/MyD88 signaling in vitro and in vivo
Abstract
A hexane fraction of Saponaria officinalis and its constituent saponarin inhibited MAPK signalling, NF-kB activity and pro-inflammatory cytokine production in macrophages and reduced LPS-induced inflammation in zebrafish, acting as a TLR4/MD2 complex antagonist, demonstrating an anti-inflammatory mechanism of soapwort.
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How to cite
Yu, G.R., Lim, D.W., Karunarathne, W.A.H.M., Kim, G.Y. and others (2022) 'A non-polar fraction of Saponaria officinalis L. acted as a TLR4/MD2 complex antagonist and inhibited TLR4/MyD88 signaling in vitro and in vivo', FASEB Journal, 36(7), pp. e22387. doi:10.1096/fj.202200018RR
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