Omnia Sana · Plant Monograph
Pelargonium
Pelargonium sidoides
This monograph compiles 2 documented constituents, 2 pharmacological actions, 6 traditional / indicated uses, supported by 13 cited sources, drawn directly from the Omnia Sana plant database.
Key Constituents
Pharmacological Actions
Traditional & Indicated Uses
Acute bronchitis - reduces symptom severity and shortens illness
more plants for bronchitis →detailed sources →Cold & flu[2]Good · 7/10
Common cold and acute respiratory tract infection
more plants for cold & flu →detailed sources →Immune support[12]Traditional · 2/10
inferred from immunomodulator action
more plants for immune support →detailed sources →Infection (general)[2]Good · 7/10
Common cold and acute respiratory tract infection
more plants for infection (general) →detailed sources →Rhinosinusitis (sinusitis) support
more plants for sinusitis →detailed sources →Sore throat[2]Good · 7/10
Sore throat / acute tonsillopharyngitis
more plants for sore throat →detailed sources →Safety, Cautions & Contraindications
Generally well tolerated; the main effects are mild gastrointestinal upset or, rarely, an allergic skin reaction. Rare reports of liver injury mean you should stop and seek advice if signs of liver problems occur.
Safety note[2]Caution
The coumarin content gives a theoretical bleeding risk, so use caution with anticoagulant medicines; use in pregnancy and breastfeeding is not recommended.
References
REF-1868, REF-0492, REF-1869, REF-1870, REF-0576, REF-1871, REF-1872, REF-1873, REF-1874, REF-1875, REF-1876References & Sources
- Moyo, M. and Van Staden, J (2014) 'Medicinal properties and conservation of Pelargonium sidoides DC', Journal of Ethnopharmacology, 152(2), pp. 243-255. doi:10.1016/j.jep.2014.01.009 Meta-analysis / review
https://doi.org/10.1016/j.jep.2014.01.009 - Careddu, D. and Pettenazzo, A (2018) 'Pelargonium sidoides extract EPs 7630: a review of its clinical efficacy and safety for treating acute respiratory tract infections in children', International Journal of General Medicine. doi:10.2147/IJGM.S154198 Meta-analysis / review
https://doi.org/10.2147/IJGM.S154198 - Timmer, A., Gunther, J., Rucker, G., Motschall, E., Antes, G. and Kern, W.V (2008) 'Pelargonium sidoides extract for acute respiratory tract infections', Cochrane Database of Systematic Reviews, (3), pp. CD006323. doi:10.1002/14651858.CD006323.pub2 Meta-analysis / review
https://doi.org/10.1002/14651858.CD006323.pub2 - Timmer, A., Gunther, J., Motschall, E., Rucker, G., Antes, G. and Kern, W.V (2013) 'Pelargonium sidoides extract for treating acute respiratory tract infections', Cochrane Database of Systematic Reviews, 2013(10), pp. CD006323. doi:10.1002/14651858.CD006323.pub3 Meta-analysis / review
https://doi.org/10.1002/14651858.CD006323.pub3 - Agbabiaka, T.B., Guo, R. and Ernst, E (2008) 'Pelargonium sidoides for acute bronchitis: a systematic review and meta-analysis', Phytomedicine, 15(5), pp. 378--385. doi:10.1016/j.phymed.2007.11.023 Meta-analysis / review
https://doi.org/10.1016/j.phymed.2007.11.023 - Kayser, O., Kolodziej, H. and Kiderlen, A.F (2001) 'Immunomodulatory principles of Pelargonium sidoides', Phytotherapy Research, 15(2), pp. 122-126. doi:10.1002/ptr.785 Preclinical
https://doi.org/10.1002/ptr.785 - Kolodziej, H. and Kiderlen, A.F (2006) 'In vitro evaluation of antibacterial and immunomodulatory activities of Pelargonium reniforme, Pelargonium sidoides and the related herbal drug preparation EPs 7630', Phytomedicine, 14(Suppl 6), pp. 18-26. doi:10.1016/j.phymed.2006.11.020 Preclinical
https://doi.org/10.1016/j.phymed.2006.11.020 - Gokce, S., Dortkardesler, B.E., Yurtseven, A. and Kurugol, Z (2021) 'Effectiveness of Pelargonium sidoides in pediatric patients diagnosed with uncomplicated upper respiratory tract infection: a single-blind, randomized, placebo-controlled study', European Journal of Pediatrics, 180(9), pp. 3019-3028. doi:10.1007/s00431-021-04211-y Randomized trial
https://doi.org/10.1007/s00431-021-04211-y - Kolodziej, H (2011) 'Antimicrobial, Antiviral and Immunomodulatory Activity Studies of Pelargonium sidoides (EPs 7630) in the Context of Health Promotion', Pharmaceuticals, 4(10), pp. 1295-1314. doi:10.3390/ph4101295 Meta-analysis / review
https://doi.org/10.3390/ph4101295 - Roth, M., Fang, L., Stolz, D. and Tamm, M (2019) 'Pelargonium sidoides radix extract EPs 7630 reduces rhinovirus infection through modulation of viral binding proteins on human bronchial epithelial cells', PLoS One, 14(2), pp. e0210702. doi:10.1371/journal.pone.0210702 Clinical study
https://doi.org/10.1371/journal.pone.0210702 - Willcox, M., Simpson, C., Wilding, S., Stuart, B., Soilemezi, D., Whitehead, A., Morgan, A., Wrixon, E., Zhu, S., Yao, G., Webley, F., Yan, R., Bostock, J., Bell, M., Griffiths, G., Leydon, G., Little, P., Butler, C., Hay, A.D. and Moore, M (2021) 'Pelargonium sidoides root extract for the treatment of acute cough due to lower respiratory tract infection in adults: a feasibility double-blind, placebo-controlled randomised trial', BMC Complementary Medicine and Therapies, 21(1), pp. 48. doi:10.1186/s12906-021-03206-4 Randomized trial
https://doi.org/10.1186/s12906-021-03206-4 - Conrad, A., Kolodziej, H. and Schulz, V (2007) 'Pelargonium sidoides-extract (EPs 7630): registration confirms efficacy and safety', Wiener Medizinische Wochenschrift. doi:10.1007/s10354-007-0434-6 Preclinical
https://doi.org/10.1007/s10354-007-0434-6 - Koch, A.K., Klose, P., Lauche, R., Cramer, H., Baasch, J., Dobos, G.J. and Langhorst, J (2016) 'A Systematic Review of Phytotherapy for Acute Rhinosinusitis', Forschende Komplementarmedizin, 23(3), pp. 165--169. doi:10.1159/000447467 Meta-analysis / review
https://doi.org/10.1159/000447467
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