Omnia Sana · Plant Monograph
Oyster mushroom
Pleurotus ostreatus
This monograph compiles 5 pharmacological actions, 8 traditional / indicated uses, supported by 12 cited sources, drawn directly from the Omnia Sana plant database.
Pharmacological Actions
Traditional & Indicated Uses
Arthritis / joint pain[11]Moderate · 5/10
inferred from anti-inflammatory action
more plants for arthritis / joint pain →detailed sources →inferred from antidiabetic action
more plants for blood sugar / diabetes support →detailed sources →Cold & flu[11]Moderate · 5/10
inferred from immunomodulator action
more plants for cold & flu →detailed sources →Immune support[11]Moderate · 5/10
more plants for immune support →detailed sources →Inflammation (general)[11]Moderate · 5/10
inferred from anti-inflammatory action
more plants for inflammation (general) →detailed sources →inferred from antidiabetic action
more plants for metabolic support →detailed sources →Skin irritation[11]Moderate · 5/10
inferred from anti-inflammatory action
more plants for skin irritation →detailed sources →Safety, Cautions & Contraindications
Generally very safe as a food. Rare cases of occupational asthma and allergy reported among people working with mushroom cultivation. Safe for culinary use without significant known interactions.
References
REF-1496, REF-1497, REF-1498, REF-1499, REF-1500, REF-1501, REF-1502, REF-1503, REF-1504, REF-1505References & Sources
- Motta, F., Gershwin, M.E. and Selmi, C (2021) 'Mushrooms and immunity', Journal of Autoimmunity, 117, pp. 102576. doi:10.1016/j.jaut.2020.102576 Meta-analysis / review
https://doi.org/10.1016/j.jaut.2020.102576 - Toros, G., El-Ramady, H., Prokisch, J., Velasco, F. and others (2023) 'Modulation of the Gut Microbiota with Prebiotics and Antimicrobial Agents from Pleurotus ostreatus Mushroom', Foods, 12(10), pp. 2010. doi:10.3390/foods12102010 Preclinical
https://doi.org/10.3390/foods12102010 - Mishra, V., Tomar, S., Yadav, P. and Singh, M.P (2021) 'Promising anticancer activity of polysaccharides and other macromolecules derived from oyster mushroom (Pleurotus sp.): An updated review', International Journal of Biological Macromolecules, 182, pp. 1628-1637. doi:10.1016/j.ijbiomac.2021.05.102 Meta-analysis / review
https://doi.org/10.1016/j.ijbiomac.2021.05.102 - Gu, Y.H. and Sivam, G (2006) 'Cytotoxic effect of oyster mushroom Pleurotus ostreatus on human androgen-independent prostate cancer PC-3 cells', Journal of Medicinal Food, 9(2), pp. 196-204. doi:10.1089/jmf.2006.9.196 Preclinical
https://doi.org/10.1089/jmf.2006.9.196 - Sharma, A., Sharma, A. and Tripathi, A (2021) 'Biological activities of Pleurotus spp. polysaccharides: A review', Journal of Food Biochemistry, 45(6), pp. e13748. doi:10.1111/jfbc.13748 Meta-analysis / review
https://doi.org/10.1111/jfbc.13748 - Krupodorova, T., Barshteyn, V., Tsygankova, V., Sevindik, M. and others (2024) 'Strain-specific features of Pleurotus ostreatus growth in vitro and some of its biological activities', BMC Biotechnology, 24(1), pp. 9. doi:10.1186/s12896-024-00834-9 Preclinical
https://doi.org/10.1186/s12896-024-00834-9 - Perez-Bassart, Z., Bauerl, C., Fabra, M.J., Martinez-Abad, A. and others (2023) 'Composition, structural properties and immunomodulatory activity of several aqueous Pleurotus beta-glucan-rich extracts', International Journal of Biological Macromolecules, 253(Pt 6), pp. 127255. doi:10.1016/j.ijbiomac.2023.127255 Preclinical
https://doi.org/10.1016/j.ijbiomac.2023.127255 - Dos Santos, J.F., de Oliveira, N.M.T., da Silva Milhorini, S., Rutckeviski, R. and others (2025) 'The use of Pleurotus ostreatus by-products for the preparation of a gel-like polysaccharide with bioactive properties', International Journal of Biological Macromolecules, 301, pp. 140236. doi:10.1016/j.ijbiomac.2025.140236 Preclinical
https://doi.org/10.1016/j.ijbiomac.2025.140236 - Huang, X. and Nie, S (2015) 'The structure of mushroom polysaccharides and their beneficial role in health', Food & Function, 6(10), pp. 3205-3217. doi:10.1039/c5fo00678c Meta-analysis / review
https://doi.org/10.1039/c5fo00678c - Drezek, J. and Mozejko-Ciesielska, J (2025) 'Production of beta-Glucans by Pleurotus ostreatus: Cultivation and Genetic Background', International Journal of Molecular Sciences, 26(19), pp. 9703. doi:10.3390/ijms26199703 Preclinical
https://doi.org/10.3390/ijms26199703 - Wasser, S.P (2011) 'Current findings, future trends, and unsolved problems in studies of medicinal mushrooms', 89(5), pp. 1323--1332. Randomized trial
Find this source - Guillamon, E. et al (2010) 'Edible mushrooms: role in the prevention of cardiovascular diseases', 81(7), pp. 715--723. Clinical study
Find this source
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